Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines.
Adaptive Immunity
/ immunology
Adolescent
BCG Vaccine
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
Child
Cytokines
/ metabolism
Humans
Immunity, Innate
/ immunology
Interferon-gamma
/ metabolism
Mycobacterium tuberculosis
/ immunology
Natural Killer T-Cells
/ immunology
Th1 Cells
/ immunology
Tuberculosis Vaccines
/ immunology
Tuberculosis, Pulmonary
/ immunology
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
09 10 2020
09 10 2020
Historique:
received:
26
03
2020
accepted:
11
09
2020
entrez:
10
10
2020
pubmed:
11
10
2020
medline:
22
6
2021
Statut:
epublish
Résumé
We characterize the breadth, function and phenotype of innate and adaptive cellular responses in a prevention of Mycobacterium tuberculosis infection trial. Responses are measured by whole blood intracellular cytokine staining at baseline and 70 days after vaccination with H4:IC31 (subunit vaccine containing Ag85B and TB10.4), Bacille Calmette-Guerin (BCG, a live attenuated vaccine) or placebo (n = ~30 per group). H4:IC31 vaccination induces Ag85B and TB10.4-specific CD4 T cells, and an unexpected NKT
Identifiants
pubmed: 33037320
doi: 10.1038/s42003-020-01288-3
pii: 10.1038/s42003-020-01288-3
pmc: PMC7547090
doi:
Substances chimiques
BCG Vaccine
0
Cytokines
0
Tuberculosis Vaccines
0
Interferon-gamma
82115-62-6
Types de publication
Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
563Subventions
Organisme : Wellcome Trust
ID : 211360/Z/18/Z
Pays : United Kingdom
Investigateurs
Charmaine Abrahams
(C)
Marcelene Aderiye
(M)
Hadn Africa
(H)
Deidre Albertyn
(D)
Fadia Alexander
(F)
Julia Amsterdam
(J)
Peter Andersen
(P)
Denis Arendsen
(D)
Hanlie Bester
(H)
Elizabeth Beyers
(E)
Natasja Botes
(N)
Janelle Botes
(J)
Samentra Braaf
(S)
Roger Brooks
(R)
Yolundi Cloete
(Y)
Alessandro Companie
(A)
Kristin Croucher
(K)
Ilse Davids
(I)
Guy de Bruyn
(G)
Bongani Diamond
(B)
Portia Dlakavu
(P)
Palesa Dolo
(P)
Sahlah Dubel
(S)
Cindy Elbring
(C)
Ruth D Ellis
(RD)
Margareth Erasmus
(M)
Terence Esterhuizen
(T)
Thomas Evans
(T)
Christine Fattore
(C)
Sebastian Gelderbloem
(S)
Diann Gempies
(D)
Sandra Goliath
(S)
Peggy Gomes
(P)
Yolande Gregg
(Y)
Elizabeth Hamilton
(E)
Willem A Hanekom
(WA)
Johanna Hector
(J)
Roxanne Herling
(R)
Yulandi Herselman
(Y)
Robert Hopkins
(R)
Jane Hughes
(J)
Devin Hunt
(D)
Henry Issel
(H)
Helene Janosczyk
(H)
Lungisa Jaxa
(L)
Carolyn Jones
(C)
Jateel Kassiem
(J)
Sophie Keffers
(S)
Xoliswa Kelepu
(X)
Alana Keyser
(A)
Alexia Kieffer
(A)
Ingrid Kromann
(I)
Sandra Kruger
(S)
Maureen Lambrick
(M)
Bernard Landry
(B)
Phumzile Langata
(P)
Maria Lempicki
(M)
Marie-Christine Locas
(MC)
Angelique Luabeya
(A)
Lauren Mactavie
(L)
Lydia Makunzi
(L)
Pamela Mangala
(P)
Clive Maqubela
(C)
Boitumelo Mosito
(B)
Angelique Mouton
(A)
Humphrey Mulenga
(H)
Mariana Mullins
(M)
Julia Noble
(J)
Onke Nombida
(O)
Dawn O'Dee
(D)
Amy O'Neil
(A)
Rose Ockhuis
(R)
Saleha Omarjee
(S)
Fajwa Opperman
(F)
Dhaval Patel
(D)
Christel Petersen
(C)
Abraham Pretorius
(A)
Debbie Pretorius
(D)
Michael Raine
(M)
Rodney Raphela
(R)
Maigan Ratangee
(M)
Christian Rauner
(C)
Susan Rossouw
(S)
Surita Roux
(S)
Kathryn Tucker Rutkowski
(KT)
Robert Ryall
(R)
Elisma Schoeman
(E)
Constance Schreuder
(C)
Steven G Self
(SG)
Cashwin September
(C)
Justin Shenje
(J)
Barbara Shepherd
(B)
Heather Siefers
(H)
Eunice Sinandile
(E)
Danna Skea
(D)
Marcia Steyn
(M)
Jin Su
(J)
Sharon Sutton
(S)
Anne Swarts
(A)
Patrick Syntin
(P)
Michele Tameris
(M)
Petrus Tyambetyu
(P)
Arrie van der Merwe
(A)
Elize van der Riet
(E)
Dorothy van der Vendt
(D)
Denise van der Westhuizen
(D)
Anja van der Westhuizen
(A)
Elma van Rooyen
(E)
Ashley Veldsman
(A)
Helen Veltdsman
(H)
Emerencia Vermeulen
(E)
Sindile Wiseman Matiwane
(SW)
Noncedo Xoyana
(N)
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