Fluorescent Nanoparticles Coated with a Somatostatin Analogue Target Blood Monocyte for Efficient Leukaemia Treatment.
PEGylated quantum dots
fluorescent nanoparticles, leukaemia, active targeting
octreotide
somatostatin receptors
Journal
Pharmaceutical research
ISSN: 1573-904X
Titre abrégé: Pharm Res
Pays: United States
ID NLM: 8406521
Informations de publication
Date de publication:
09 Oct 2020
09 Oct 2020
Historique:
received:
07
05
2020
accepted:
23
09
2020
entrez:
10
10
2020
pubmed:
11
10
2020
medline:
15
7
2021
Statut:
epublish
Résumé
Leukaemia is the most prevalent form of cancer-causing death in a large number of populations and needs prompt and effective treatment. Chemotherapeutics can be used to treat leukaemia, but their pronounced killing effects to other living cells is still an issue. Active targeting to certain specific receptors in leukaemic cells is the best way to avoid damage to other living cells. Leukaemic cells can be targeted using novel nanoparticles (NPs) coated with a specific ligand, such as octreotide (OCD), to target somatostatin receptor type 2 (SSTR Amino-PEGylated quantum dots (QDs) were chosen as model NPs. The QDs were first succinylated using succinic anhydride and then coated with OCD. The reactivity and selectivity of the formulated QDs-OCD were studied in cell lines with well-expressed SSTR Highly stable QDs coated with OCD were prepared. FACS and CLSM showed highly definite interactions with overexpressed SSTR The formulated novel QDs-OCD can target SSTR
Sections du résumé
BACKGROUND
BACKGROUND
Leukaemia is the most prevalent form of cancer-causing death in a large number of populations and needs prompt and effective treatment. Chemotherapeutics can be used to treat leukaemia, but their pronounced killing effects to other living cells is still an issue. Active targeting to certain specific receptors in leukaemic cells is the best way to avoid damage to other living cells. Leukaemic cells can be targeted using novel nanoparticles (NPs) coated with a specific ligand, such as octreotide (OCD), to target somatostatin receptor type 2 (SSTR
METHODS
METHODS
Amino-PEGylated quantum dots (QDs) were chosen as model NPs. The QDs were first succinylated using succinic anhydride and then coated with OCD. The reactivity and selectivity of the formulated QDs-OCD were studied in cell lines with well-expressed SSTR
RESULTS
RESULTS
Highly stable QDs coated with OCD were prepared. FACS and CLSM showed highly definite interactions with overexpressed SSTR
CONCLUSION
CONCLUSIONS
The formulated novel QDs-OCD can target SSTR
Identifiants
pubmed: 33037505
doi: 10.1007/s11095-020-02938-1
pii: 10.1007/s11095-020-02938-1
doi:
Substances chimiques
Antineoplastic Agents
0
Fluorescent Dyes
0
Receptors, Somatostatin
0
SSTR2 protein, human
0
Sstr2 protein, mouse
0
Octreotide
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Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM