Urinary podocyte-derived microparticles in youth with type 1 and type 2 diabetes.
Acute Kidney Injury
/ etiology
Adolescent
Blood Glucose
/ metabolism
Blood Pressure
Cell-Derived Microparticles
/ metabolism
Creatinine
/ urine
Diabetes Mellitus, Type 1
/ complications
Diabetes Mellitus, Type 2
/ complications
Diabetic Nephropathies
/ etiology
Female
Flow Cytometry
Glomerular Filtration Rate
Glycated Hemoglobin
/ metabolism
Humans
Male
Podocytes
/ metabolism
Urine
/ chemistry
Albuminuria
Blood pressure
Hyperglycaemia
Microparticles
Podocytes
Type 1 diabetes
Type 2 diabetes
Urine
Youth
eGFR
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
22
06
2020
accepted:
18
08
2020
pubmed:
11
10
2020
medline:
21
1
2022
entrez:
10
10
2020
Statut:
ppublish
Résumé
The release of podocyte-derived microparticles into the urine may reflect early kidney injury in diabetes. We measured the urinary excretion of podocyte-derived microparticles in youth with type 1 and type 2 diabetes, and related the values to blood pressure, renal function and blood glucose levels. Cross-sectional, exploratory analysis of urine samples and clinical data from youth with type 1 (n = 53) and type 2 (n = 50) diabetes was carried out. Urinary podocyte-derived microparticle numbers, measured by flow cytometry, were assessed in relation to measures of blood glucose levels and renal function. Podocyte-derived microparticle excretion (MPE) normalised to urinary creatinine (MP/UCr) was higher in type 1 vs type 2 diabetes (median [IQR] MP/UCr: 7.88 [8.97] vs 1.84 [8.62]; p < 0.0001), despite the type 2 diabetes group having higher blood pressure (systolic blood pressure, median [range]: 124 [110-154] vs 114 [94-143] mmHg) and higher proportions of microalbuminuria (44.0% vs 13.2%), but shorter time since diabetes diagnosis (median [range]: 1.2 [0.0-7.0] vs 6.4 [2.0-13.9] years), than the type 1 diabetes cohort. MPE in youth with type 1 diabetes was associated with blood glucose (p = 0.01) and eGFR (p = 0.03) but not HbA Significant associations between podocyte MPE, blood glucose levels and eGFR were observed in youth with type 1 diabetes but not in those with type 2 diabetes, notwithstanding increased renal pathology in the type 2 diabetes cohort. These findings suggest that podocyte injury differs in the two diabetes cohorts. Graphical abstract.
Identifiants
pubmed: 33037887
doi: 10.1007/s00125-020-05297-z
pii: 10.1007/s00125-020-05297-z
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
469-475Subventions
Organisme : Canadian Institute of Health Research Operating Grant
ID : MOP-343810,
Commentaires et corrections
Type : ErratumIn
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