How to bridle a neutrophil.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
10
05
2020
revised:
12
08
2020
accepted:
13
08
2020
pubmed:
11
10
2020
medline:
15
12
2021
entrez:
10
10
2020
Statut:
ppublish
Résumé
Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.
Identifiants
pubmed: 33038850
pii: S0952-7915(20)30079-0
doi: 10.1016/j.coi.2020.08.003
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-47Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.