Cytokine Storms in Cancer and COVID-19.

Betacoronavirus / immunology COVID-19 Coronavirus Infections / complications Cytokines / blood Humans Inflammation / etiology Neoplasms / blood Pandemics Pneumonia, Viral / complications SARS-CoV-2 Severity of Illness Index

Journal

Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617

Informations de publication

Date de publication:
09 11 2020
Historique:
pubmed: 12 10 2020
medline: 1 12 2020
entrez: 11 10 2020
Statut: ppublish

Résumé

During the COVID-19 pandemic, research on "cytokine storms" has been reinvigorated in the field of infectious disease, but it also has particular relevance to cancer research. Interleukin-6 (IL-6) has emerged as a key component of the immune response to SARS-CoV-2, such that the repurposing of anti-IL-6 therapeutics for COVID-19 is now a major line of investigation, with several ongoing clinical trials. We lay a framework for understanding the role of IL-6 in the context of cancer research and COVID-19 and suggest how lessons learned from cancer research may impact SARS-CoV-2 research and vice versa.

Identifiants

DOI: 10.1016/j.ccell.2020.09.019 PMID: 33038939 PMC: PMC7531591
pubmed: 33038939
pii: S1535-6108(20)30493-1
doi: 10.1016/j.ccell.2020.09.019
pmc: PMC7531591
pii:
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

598-601

Informations de copyright

Published by Elsevier Inc.

Références

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Auteurs

Casmir Turnquist (C)

University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Bríd M Ryan (BM)

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Izumi Horikawa (I)

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Brent T Harris (BT)

Departments of Neurology and Pathology, Georgetown University Medical Center, Washington, DC 20007, USA.

Curtis C Harris (CC)

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Electronic address: curtis_harris@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Nidovirales › Infections à Coronaviridae › Infections à coronavirus › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › Tumeurs › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Cytokine Storms in Cancer and COVID-19.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Cytokine Storms in Cancer and COVID-19.