Parthanatos in the pathogenesis of nervous system diseases.
glioma
neurodegenerative disease
parthanatos
spinal cord injury
stroke
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
21 11 2020
21 11 2020
Historique:
received:
08
08
2020
revised:
16
09
2020
accepted:
22
09
2020
pubmed:
12
10
2020
medline:
15
5
2021
entrez:
11
10
2020
Statut:
ppublish
Résumé
Parthanatos is a modality of regulated cell death initiated by poly(ADP-ribose) polymerase 1 (PARP-1) hyperactivation and characterized by apoptosis inducing factor (AIF)-dependent and microphage migration inhibitory factor (MIF)-dependent DNA degradation. It is a caspase-independent, mitochondrial-linked paradigm of cell death and has been demonstrated to be related to the pathogenesis of various nervous system diseases. An in-depth understanding of the role that parthanatos plays in the pathological processes of these diseases can provide new targets for nervous system diseases treatments. In this review, on the basis of parthanatos mechanism, the involvement of parthanatos in the pathogenesis of nervous system diseases including neurodegenerative disorders, cerebrovascular diseases, spinal cord injury and glioma will be summarized in detail.
Identifiants
pubmed: 33039521
pii: S0306-4522(20)30639-4
doi: 10.1016/j.neuroscience.2020.09.049
pii:
doi:
Substances chimiques
Apoptosis Inducing Factor
0
Poly (ADP-Ribose) Polymerase-1
EC 2.4.2.30
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-250Informations de copyright
Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.