Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B
Aged
COVID-19
/ therapy
Cohort Studies
Critical Care
Disease Progression
Female
Hospitalization
Humans
Magnesium
/ therapeutic use
Male
Micronutrients
/ therapeutic use
Middle Aged
Minerals
/ therapeutic use
Multivariate Analysis
Oxygen Inhalation Therapy
Pandemics
SARS-CoV-2
Severity of Illness Index
Vitamin B 12
/ therapeutic use
Vitamin D
/ therapeutic use
Vitamins
/ therapeutic use
COVID-19 Drug Treatment
Magnesium
Vitamin B(12)COVID-19
Vitamin D
Journal
Nutrition (Burbank, Los Angeles County, Calif.)
ISSN: 1873-1244
Titre abrégé: Nutrition
Pays: United States
ID NLM: 8802712
Informations de publication
Date de publication:
Historique:
received:
24
06
2020
revised:
25
08
2020
accepted:
01
09
2020
pubmed:
12
10
2020
medline:
15
12
2020
entrez:
11
10
2020
Statut:
ppublish
Résumé
The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B This was a cohort observational study of all consecutive hospitalized patients ≥50 y of age with COVID-19 in a tertiary academic hospital. Before April 6, 2020, no patients received the (DMB) combination. After this date, patients were administered 1000 IU/d oral vitamin D Between January 15 and April 15, 2020, we identified 43 consecutive patients ≥50 y of age with COVID-19. Seventeen patients received DMB before onset of primary outcome and 26 patients did not. Baseline demographic characteristics between the two groups were significantly different by age. In univariate analysis, age and hypertension had a significant influence on outcome. After adjusting for age or hypertension separately in a multivariate analysis, the intervention group retained protective significance. Fewer treated patients than controls required initiation of oxygen therapy during hospitalization (17.6 vs 61.5%, P = 0.006). DMB exposure was associated with odds ratios of 0.13 (95% confidence interval [CI], 0.03-0.59) and 0.20 (95% CI, 0.04-0.93) for oxygen therapy, intensive care support, or both on univariate and multivariate analyses, respectively. A vitamin D / magnesium / vitamin B
Identifiants
pubmed: 33039952
pii: S0899-9007(20)30300-2
doi: 10.1016/j.nut.2020.111017
pmc: PMC7832811
pii:
doi:
Substances chimiques
Micronutrients
0
Minerals
0
Vitamins
0
Vitamin D
1406-16-2
Magnesium
I38ZP9992A
Vitamin B 12
P6YC3EG204
Types de publication
Clinical Trial
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
111017Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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