Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging.
Adult
Anti-HIV Agents
/ therapeutic use
Dyspnea
/ diagnosis
Exercise Test
Exercise Tolerance
Female
HIV Infections
/ complications
Humans
Lung
/ physiopathology
Magnetic Resonance Imaging
Male
Middle Aged
Oxygen Consumption
Predictive Value of Tests
Prospective Studies
Pulmonary Ventilation
Risk Factors
Ventricular Function
CPET
Contractile Reserve
Exercise CMR
HIV
Journal
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Titre abrégé: J Cardiovasc Magn Reson
Pays: England
ID NLM: 9815616
Informations de publication
Date de publication:
12 10 2020
12 10 2020
Historique:
received:
20
11
2019
accepted:
25
08
2020
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Human Immunodeficiency Virus (HIV) patients commonly experience dyspnea for which an immediate cause may not be always apparent. In this prospective cohort study of HIV patients with exercise limitation, we use cardiopulmonary exercise testing (CPET) coupled with exercise cardiovascular magnetic resonance (CMR) to elucidate etiologies of dyspnea. Thirty-four HIV patients on antiretroviral therapy with dyspnea and exercise limitation (49.7 years, 65% male, mean absolute CD4 count 700) underwent comprehensive evaluation with combined rest and maximal exercise treadmill CMR and CPET. The overall mean oxygen consumption (VO Well treated patients with HIV appear to have conserved RV and LV function, contractile reserve and no evidence of exercise induced PAH. However, we found evidence of impaired ventilation suggesting a non-cardiopulmonary etiology for dyspnea.
Identifiants
pubmed: 33040733
doi: 10.1186/s12968-020-00664-6
pii: 10.1186/s12968-020-00664-6
pmc: PMC7549205
doi:
Substances chimiques
Anti-HIV Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
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