Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities.
Kupffer cells
liver cancer
liver fibrosis
liver inflammation
monocyte-derived macrophages
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
01
09
2020
accepted:
14
09
2020
pubmed:
13
10
2020
medline:
28
12
2021
entrez:
12
10
2020
Statut:
ppublish
Résumé
Macrophages, which are key cellular components of the liver, have emerged as essential players in the maintenance of hepatic homeostasis and in injury and repair processes in acute and chronic liver diseases. Upon liver injury, resident Kupffer cells (KCs) sense disturbances in homeostasis, interact with hepatic cell populations and release chemokines to recruit circulating leukocytes, including monocytes, which subsequently differentiate into monocyte-derived macrophages (MoMϕs) in the liver. Both KCs and MoMϕs contribute to both the progression and resolution of tissue inflammation and injury in various liver diseases. The diversity of hepatic macrophage subsets and their plasticity explain their different functional responses in distinct liver diseases. In this review, we highlight novel findings regarding the origins and functions of hepatic macrophages and discuss the potential of targeting macrophages as a therapeutic strategy for liver disease.
Identifiants
pubmed: 33041338
doi: 10.1038/s41423-020-00558-8
pii: 10.1038/s41423-020-00558-8
pmc: PMC7852525
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-56Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK121330
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122796
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122708
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109574
Pays : United States
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