Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease.
chronic kidney disease
endoplasmic reticulum stress
saturated fatty acid
skeletal muscle atrophy
stearoyl-CoA desaturase
Journal
Journal of clinical biochemistry and nutrition
ISSN: 0912-0009
Titre abrégé: J Clin Biochem Nutr
Pays: Japan
ID NLM: 8700907
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
25
02
2020
accepted:
11
03
2020
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
13
10
2020
Statut:
ppublish
Résumé
Skeletal muscle atrophy is associated with mortality and poor prognosis in patients with chronic kidney disease (CKD). However, underlying mechanism by which CKD causes muscle atrophy has not been completely understood. The quality of lipids (lipoquality), which is defined as the functional features of diverse lipid species, has recently been recognized as the pathology of various diseases. In this study, we investigated the roles of the stearoyl-CoA desaturase (SCD), which catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, in skeletal muscle on muscle atrophy in CKD model animals. In comparison to control rats, CKD rats decreased the SCD activity and its gene expression in atrophic gastrocnemius muscle. Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. Furthermore, endoplasmic reticulum stress inhibitor ameliorated CKD-induced muscle atrophy (the weakness of grip strength and the decrease of muscle fiber size of gastrocnemius muscle) in mice and the reduction of the thickness of C2C12 myotubes by SCD inhibitor. These results suggest that the repression of SCD activity causes muscle atrophy through excessive endoplasmic reticulum stress in CKD.
Identifiants
pubmed: 33041516
doi: 10.3164/jcbn.20-24
pii: DN/JST.JSTAGE/jcbn/20-24
pmc: PMC7533850
doi:
Types de publication
Journal Article
Langues
eng
Pagination
179-187Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL117062
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132318
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133545
Pays : United States
Informations de copyright
Copyright © 2020 JCBN.
Déclaration de conflit d'intérêts
No potential conflicts of interest were disclosed.
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