Biodegradable fluorescent nanoparticles for endoscopic detection of colorectal carcinogenesis.

Biodegradable colorectal lesions endoscopy fluorescent nanoparticles imaging

Journal

Advanced functional materials
ISSN: 1616-301X
Titre abrégé: Adv Funct Mater
Pays: Germany
ID NLM: 101190390

Informations de publication

Date de publication:
19 Dec 2019
Historique:
entrez: 12 10 2020
pubmed: 13 10 2020
medline: 13 10 2020
Statut: ppublish

Résumé

Early and comprehensive endoscopic detection of colonic dysplasia - the most clinically significant precursor lesion to colorectal adenocarcinoma - provides an opportunity for timely, minimally-invasive intervention to prevent malignant transformation. Here, the development and evaluation of biodegradable near-infrared fluorescent silica nanoparticles (FSN) is described that have the potential to improve adenoma detection during fluorescence-assisted white-light colonoscopic surveillance in rodent and human-scale models of colorectal carcinogenesis. FSNs are biodegradable (t

Identifiants

pubmed: 33041743
doi: 10.1002/adfm.201904992
pmc: PMC7546531
mid: NIHMS1054949
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : R01 CA182043
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA199075
Pays : United States

Déclaration de conflit d'intérêts

Conflict of Interest S.H. is an inventor on a provisional patent that has been filed by the Office of Technology Transfer at Stanford University related to the design and application of biodegradable fluorescent nanoparticles for early endoscopic (pre)malignant lesion detection.

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Auteurs

Stephan Rogalla (S)

Molecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Krzysztof Flisikowski (K)

Chair of Livestock Biotechnology, Technische Universität München, Liesel-Beckmann Str. 1, D-85354 Freising, Germany.

Dimitris Gorpas (D)

Helmholtz Zentrum München, German Researcg Center for Environmental Health, Institute of Biological and Medical Imaging, Ingolstädter Landstr. 1, D-85764, Neuherberg, Germany.

Aaron T Mayer (AT)

Molecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Tatiana Flisikowska (T)

Chair of Livestock Biotechnology, Technische Universität München, Liesel-Beckmann Str. 1, D-85354 Freising, Germany.

Michael J Mandella (MJ)

Molecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Xiaopeng Ma (X)

Helmholtz Zentrum München, German Researcg Center for Environmental Health, Institute of Biological and Medical Imaging, Ingolstädter Landstr. 1, D-85764, Neuherberg, Germany.

Kerriann M Casey (KM)

Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Stephen A Felt (SA)

Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Dieter Saur (D)

Department of Internal Medicine II, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany.

Vasilis Ntziachristos (V)

Helmholtz Zentrum München, German Researcg Center for Environmental Health, Institute of Biological and Medical Imaging, Ingolstädter Landstr. 1, D-85764, Neuherberg, Germany.

Angelika Schnieke (A)

Chair of Livestock Biotechnology, Technische Universität München, Liesel-Beckmann Str. 1, D-85354 Freising, Germany.

Christopher H Contag (CH)

Institute for Quantitative Health Science and Engineering, Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, MI 48824, USA.

Sanjiv S Gambhir (SS)

Molecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Stefan Harmsen (S)

Molecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Classifications MeSH