Pharmacogenetics in Psychiatry: An Update on Clinical Usability.
CYP2C19
CYP2D6
antidepressant
cytochrome P450
depression
pharmacogenetics
psychiatry
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
06
2020
accepted:
25
08
2020
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
13
10
2020
Statut:
epublish
Résumé
Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regarding genotyping (SNP analysis/arrays/NGS), structural variant detection (star-alleles/CNVs/hybrid alleles), genotype-to-phenotype translations, cost-effectiveness, and actionability of results (FDA/CPIC/PharmGKB) regarding clinical importance of pre-emptive pharmacogenomic testing for prescription of antidepressants and antipsychotics.
Identifiants
pubmed: 33041820
doi: 10.3389/fphar.2020.575540
pmc: PMC7518035
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
575540Informations de copyright
Copyright © 2020 van Schaik, Müller, Serretti and Ingelman-Sundberg.
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