Sphingolipids in the Heart: From Cradle to Grave.
cardiovascular disease
ceramide
heart development
sphingolipids
sphingosine-1-phosphate
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
06
2020
accepted:
11
08
2020
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
26
5
2021
Statut:
epublish
Résumé
Cardiovascular diseases are the leading cause of mortality worldwide and this has largely been driven by the increase in metabolic disease in recent decades. Metabolic disease alters metabolism, distribution, and profiles of sphingolipids in multiple organs and tissues; as such, sphingolipid metabolism and signaling have been vigorously studied as contributors to metabolic pathophysiology in various pathological outcomes of obesity, including cardiovascular disease. Much experimental evidence suggests that targeting sphingolipid metabolism may be advantageous in the context of cardiometabolic disease. The heart, however, is a structurally and functionally complex organ where bioactive sphingolipids have been shown not only to mediate pathological processes, but also to contribute to essential functions in cardiogenesis and cardiac function. Additionally, some sphingolipids are protective in the context of ischemia/reperfusion injury. In addition to mechanistic contributions, untargeted lipidomics approaches used in recent years have identified some specific circulating sphingolipids as novel biomarkers in the context of cardiovascular disease. In this review, we summarize recent literature on both deleterious and beneficial contributions of sphingolipids to cardiogenesis and myocardial function as well as recent identification of novel sphingolipid biomarkers for cardiovascular disease risk prediction and diagnosis.
Identifiants
pubmed: 33042014
doi: 10.3389/fendo.2020.00652
pmc: PMC7522163
doi:
Substances chimiques
Sphingolipids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
652Subventions
Organisme : BLRD VA
ID : I01 BX000200
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151243
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117233
Pays : United States
Informations de copyright
Copyright © 2020 Kovilakath, Jamil and Cowart.
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