A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration.
Animals
Antibodies, Monoclonal, Humanized
/ therapeutic use
Antibodies, Neutralizing
/ therapeutic use
Arthritis, Rheumatoid
/ drug therapy
Carcinogenesis
Clinical Trials as Topic
Humans
Immunity, Innate
/ physiology
Infections
/ immunology
Inflammation
/ physiopathology
Interleukins
/ adverse effects
Mice
Mucus
/ metabolism
Neoplasms
/ etiology
Psoriasis
/ drug therapy
Receptors, Interleukin
/ physiology
Regeneration
/ physiology
T-Lymphocyte Subsets
/ immunology
Wound Healing
/ physiology
Interleukin-22
IL22-producing cells
carcinogenesis and metastasis
innate immune response and inflammation
tissue regeneration
wound healing—physiopathology
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
05
2020
accepted:
07
08
2020
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
7
5
2021
Statut:
epublish
Résumé
Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events include release of a number of cytokines to accomplish post-trauma restoration. IL-22 is one of the cytokines that are immediately produced to initiate immune response against several tissue impairments. IL-22 is a fundamental mediator in inflammation, mucous production, protective role against pathogens, wound healing, and tissue regeneration. However, accumulating evidence suggests pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. In this review, we summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis.
Identifiants
pubmed: 33042126
doi: 10.3389/fimmu.2020.02148
pmc: PMC7527413
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Antibodies, Neutralizing
0
IL22RA2 protein, human
0
Interleukins
0
Receptors, Interleukin
0
interleukin-22 receptor
0
fezakinumab
0S77U25XZ3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2148Informations de copyright
Copyright © 2020 Arshad, Mansur, Palek, Manzoor and Liska.
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