Immunohistochemical detection of paralogous 13 HOX genes in phyllodes tumor of the breast as a useful diagnostic tool.
Paralogous 13 HOX genes
breast phyllodes tumors
diagnostic marker
Journal
International journal of clinical and experimental pathology
ISSN: 1936-2625
Titre abrégé: Int J Clin Exp Pathol
Pays: United States
ID NLM: 101480565
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
08
2019
accepted:
27
08
2019
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
13
10
2020
Statut:
epublish
Résumé
Phyllodes tumor of the breast is a rare fibroepithelial lesion characterized by a propensity for local recurrence and distant metastasis. Its histologic classification, based on morphology, mitotic index and tumor margin, includes malignant, borderline, and benign. These tumors show similar cellular morphology, which may contribute to difficulty in classifying them histologically and in prediction of their clinical behavior. Thus, the identification of new biomarkers detectable also by in situ methods has become indispensable. Paralogous HOX13 genes (HOX A13, HOX B13, HOX C13 and HOX D13) play a relevant role in tumor development and progression in particular in breast cancer. In this study we analyzed the immunohistochemical expression of paralogous HOX13 homeoproteins on a phyllodes tumor case series to validate their usefulness in histologic classification.
Types de publication
Journal Article
Langues
eng
Pagination
2348-2351Informations de copyright
IJCEP Copyright © 2020.
Déclaration de conflit d'intérêts
None.
Références
Cancers (Basel). 2019 May 20;11(5):
pubmed: 31137568
Am J Cancer Res. 2015 Sep 15;5(10):3042-55
pubmed: 26693058
Cancers (Basel). 2019 Apr 12;11(4):
pubmed: 31013831
Breast Cancer Res Treat. 2012 Feb;132(1):143-51
pubmed: 21574054
J Cell Physiol. 2001 Aug;188(2):161-9
pubmed: 11424082
Int J Mol Sci. 2013 Nov 01;14(11):21727-40
pubmed: 24189220
Histopathology. 2016 Jan;68(1):5-21
pubmed: 26768026
J Transl Med. 2018 Dec 12;16(1):350
pubmed: 30541551