Reconstructed and Real Proton Radiographs for Image-Guidance in Proton Beam Therapy.

One of the major challenges to proton beam therapy at this time is the uncertainty of the true range of a clinical treatment proton beam as it traverses the various tissues and organs in a human body. This uncertainty necessitates the addition of greater "margins" to the planning target volume along the direction of the beam to ensure safety and tumor target coverage. Proton radiography holds promise as both an image-guidance method for proton beam therapy and as a means of estimating particle beam range in the clinic. In this brief report, we present some of the first real and reconstructed proton radiographs using our particular system. Our qualitative review of these images indicates that this method has excellent potential as a proton radiography-based image guidance system. Based on the encouraging results of our preliminary work, more rigorous and quantitative analyses will be performed shortly and we shall continue to explore the potential of this approach for addressing the particle beam range uncertainty issue.

Déclaration de conflit d'intérêts

Conflict of Interest Don F. DeJongh and Victor Rykalin are co-founders of ProtonVDA, Inc., Naperville, IL, 60563, USA and Ethan A. DeJongh, is an employee of ProtonVDA, Inc. None of the other authors have relevant potential conflicts of interest. James Welsh has served in the past as an advisor to ProTom International.