Terminal differentiation of human granulosa cells as luteinization is reversed by activin-A through silencing of Jnk pathway.
Hormone receptors
Translational research
Journal
Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
04
2020
revised:
28
07
2020
accepted:
21
08
2020
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
13
10
2020
Statut:
epublish
Résumé
Molecular mechanisms underlying luteinization (terminal differentiation of granulosa and theca cells after ovulation) and luteolysis (demise of corpus luteum) are poorly understood in human ovary. Here we report that activin-A, after binding to its cognate receptors induces a functional luteolytic state and reverses luteinization phenotype by downregulating the expression of the steroidogenic enzymes, LH receptor and VEGF and reducing estradiol (E
Identifiants
pubmed: 33042587
doi: 10.1038/s41420-020-00324-9
pii: 324
pmc: PMC7511402
doi:
Types de publication
Journal Article
Langues
eng
Pagination
93Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that they have no conflict of interest.
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