An Italian Retrospective Survey on Bone Metastasis in Melanoma: Impact of Immunotherapy and Radiotherapy on Survival.

SREs bisphosphonates bone metastases denosumab immunotherapy melanoma

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2020
Historique:
received: 07 06 2020
accepted: 28 07 2020
entrez: 12 10 2020
pubmed: 13 10 2020
medline: 13 10 2020
Statut: epublish

Résumé

We performed a multicenter retrospective observational study to investigate the impact of clinical-pathological features and therapeutic strategies on both the complications and survival of patients with bone metastases (BMs) from malignant melanoma. A total of 305 patients with melanoma and radiological evidence of BMs were retrospectively enrolled from 19 Italian centers. All patients received conventional treatments in accordance with each own treating physician's practice. Both univariate and multivariate models were used to explore the impact of melanoma features, including skeletal-related events (SREs), and different treatments on both overall survival (OS) and time-to-SREs. The chi-squared test evaluated the suitability of several parameters to predict the occurrence of SREs. Eighty-three percent of patients had metachronous BMs. The prevalent (90%) bone metastatic site was the spine, while 45% had involvement of the appendicular skeleton. Forty-seven percent experienced at least one SRE, including palliative radiotherapy (RT) in 37% of cases. No melanoma-associated factor was predictive of the development of SREs, although patients receiving early treatment with bone-targeted agents showed 62% lower risk and delayed time of SRE occurrence. Median OS from the diagnosis of bone metastasis was 10.7 months. The multivariate analysis revealed as independent prognostic factors the number of BMs, number of metastatic organs, baseline lactate dehydrogenase levels, and treatment with targeted therapy or immunotherapy. Subgroup analyses showed the best OS (median = 16.5 months) in the subset of patients receiving both immunotherapy and palliative RT. Based on our results, patients undergoing immunotherapy and palliative RT showed an OS benefit suggestive of a possible additive effect. The apparent protective role of bone targeting agent use on SREs observed in our analysis should deserve prospective evaluation.

Sections du résumé

BACKGROUND BACKGROUND
We performed a multicenter retrospective observational study to investigate the impact of clinical-pathological features and therapeutic strategies on both the complications and survival of patients with bone metastases (BMs) from malignant melanoma.
PATIENTS AND METHODS METHODS
A total of 305 patients with melanoma and radiological evidence of BMs were retrospectively enrolled from 19 Italian centers. All patients received conventional treatments in accordance with each own treating physician's practice. Both univariate and multivariate models were used to explore the impact of melanoma features, including skeletal-related events (SREs), and different treatments on both overall survival (OS) and time-to-SREs. The chi-squared test evaluated the suitability of several parameters to predict the occurrence of SREs.
RESULTS RESULTS
Eighty-three percent of patients had metachronous BMs. The prevalent (90%) bone metastatic site was the spine, while 45% had involvement of the appendicular skeleton. Forty-seven percent experienced at least one SRE, including palliative radiotherapy (RT) in 37% of cases. No melanoma-associated factor was predictive of the development of SREs, although patients receiving early treatment with bone-targeted agents showed 62% lower risk and delayed time of SRE occurrence. Median OS from the diagnosis of bone metastasis was 10.7 months. The multivariate analysis revealed as independent prognostic factors the number of BMs, number of metastatic organs, baseline lactate dehydrogenase levels, and treatment with targeted therapy or immunotherapy. Subgroup analyses showed the best OS (median = 16.5 months) in the subset of patients receiving both immunotherapy and palliative RT.
CONCLUSION CONCLUSIONS
Based on our results, patients undergoing immunotherapy and palliative RT showed an OS benefit suggestive of a possible additive effect. The apparent protective role of bone targeting agent use on SREs observed in our analysis should deserve prospective evaluation.

Identifiants

pubmed: 33042809
doi: 10.3389/fonc.2020.01652
pmc: PMC7523509
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1652

Informations de copyright

Copyright © 2020 Mannavola, Mandala, Todisco, Sileni, Palla, Minisini, Pala, Morgese, Di Guardo, Stucci, Guida, Indini, Quaglino, Ferraresi, Marconcini, Tronconi, Rossi, Nigro, Occelli, Cortellini, Quadrini, Palmieri, Pigozzo, Ascierto, Vitale, Strippoli, Ferrucci, Berardi, Randon, Cardone, Schinzari, Silvestris and Tucci.

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Auteurs

Francesco Mannavola (F)

Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.

Mario Mandala (M)

Medical Oncology Unit, Department of Oncology and Hematology, Azienda Ospedaliera Papa Giovanni XXIII Hospital, Bergamo, Italy.

Annalisa Todisco (A)

Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.

Vanna Chiarion Sileni (VC)

Melanoma Oncology Unit, Veneto Institute of Oncology, Scientific Institute for Research, Hospitalization and Healthcare, Padua, Italy.

Marco Palla (M)

Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.

Alessandro Marco Minisini (AM)

Department of Oncology, Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy.

Laura Pala (L)

Division of Melanoma, Sarcoma and Rare Tumors, European Institute of Oncology, Scientific Institute for Research, Hospitalization and Healthcare, Milan, Italy.

Francesca Morgese (F)

Oncology Clinic, Università Politecnica delle Marche, Ancona, Italy.

Lorenza Di Guardo (L)

Melanoma Medical Oncology Unit, Department of Medical Oncology and Hematology, National Institute of Tumori, Milan, Italy.

Luigia Stefania Stucci (LS)

Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.

Michele Guida (M)

IRCCS Giovanni Paolo II, Cancer Institute, Bari, Italy.

Alice Indini (A)

Medical Oncology Unit, Department of Oncology and Hematology, Azienda Ospedaliera Papa Giovanni XXIII Hospital, Bergamo, Italy.

Pietro Quaglino (P)

Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy.

Virginia Ferraresi (V)

First Division of Medical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Riccardo Marconcini (R)

Medical Oncology Department, Santa Chiara Hospital, University of Pisa, Pisa, Italy.

Maria Chiara Tronconi (MC)

Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy.

Ernesto Rossi (E)

Medical Oncology, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy.

Olga Nigro (O)

Medical Oncology, ASST-Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

Marcella Occelli (M)

Medical Oncology Unit, Santa Croce and Carle Teaching Hospital, Cuneo, Italy.

Alessio Cortellini (A)

Department of Biotechnological and Applied Clinical Sciences, San Salvatore Hospital, University of L'Aquila, L'Aquila, Italy.

Silvia Quadrini (S)

Medical Oncology Unit, Azienda Sanitaria Locale Frosinone, Frosinone, Italy.

Giuseppe Palmieri (G)

Unit of Cancer Genetics, Institute of Genetic and Biomedical Research, National Research Council, Sassari, Italy.

Jacopo Pigozzo (J)

Melanoma Oncology Unit, Veneto Institute of Oncology, Scientific Institute for Research, Hospitalization and Healthcare, Padua, Italy.

Paolo Antonio Ascierto (PA)

Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.

Maria Grazia Vitale (MG)

Department of Oncology, Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy.

Sabino Strippoli (S)

IRCCS Giovanni Paolo II, Cancer Institute, Bari, Italy.

Pier Francesco Ferrucci (PF)

Division of Melanoma, Sarcoma and Rare Tumors, European Institute of Oncology, Scientific Institute for Research, Hospitalization and Healthcare, Milan, Italy.

Rossana Berardi (R)

Oncology Clinic, Università Politecnica delle Marche, Ancona, Italy.

Giovanni Randon (G)

Melanoma Medical Oncology Unit, Department of Medical Oncology and Hematology, National Institute of Tumori, Milan, Italy.

Pietro Cardone (P)

Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy.

Giovanni Schinzari (G)

Medical Oncology, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy.

Franco Silvestris (F)

Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.

Marco Tucci (M)

Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.
IRCCS Giovanni Paolo II, Cancer Institute, Bari, Italy.

Classifications MeSH