Soft Material-Enabled, Active Wireless, Thin-Film Bioelectronics for Quantitative Diagnostics of Cervical Dystonia.
Cervical dystonia
Quantitative digital assessment
Soft materials and packaging
Wearable flexible hybrid electronics
Wireless quantification of movement
Journal
Advanced materials technologies
ISSN: 2365-709X
Titre abrégé: Adv Mater Technol
Pays: United States
ID NLM: 101717732
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
13
10
2020
Statut:
ppublish
Résumé
Recent advances in flexible materials, nanomanufacturing, and system integration have provided a great opportunity to develop wearable flexible hybrid electronics for human healthcare, diagnostics, and therapeutics. However, existing medical devices still rely on rigid electronics with many wires and separate components, which hinders wireless, comfortable, continuous monitoring of health-related human motions. Here, we introduce advanced materials and system integration technologies that enable a soft, active wireless, thin-film bioelectronics. The low-modulus, highly flexible wearable electronic system incorporates a nanomembrane wireless circuit and functional chip components, enclosed by a soft elastomeric membrane. The bioelectronic system offers a gentle, seamless mounting on the skin, while offering a comfortable, highly sensitive and accurate detection of head movements. We utilize the wireless wearable hybrid system for quantitative diagnostics of cervical dystonia (CD) that is characterized by involuntary abnormal head postures and repetitive head movements, sometimes with neck muscle pain. A set of analytical and experimental studies shows a soft system packaging, hard-soft materials integration, and quantitative assessment of physiological signals detected by the SKINTRONICS.
Identifiants
pubmed: 33043125
doi: 10.1002/admt.201900458
pmc: PMC7546326
mid: NIHMS1046884
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NINDS NIH HHS
ID : U54 NS116025
Pays : United States
Organisme : NCATS NIH HHS
ID : U54 TR001456
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest W.-H.Y. and H.A.J. have a pending US patent application.
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