Microphysiological Systems: Next Generation Systems for Assessing Toxicity and Therapeutic Effects of Nanomaterials.
multi-organ-on-a-chips
nanomaterials
organ-on-a-chips
personalized medicine
toxicity
Journal
Small methods
ISSN: 2366-9608
Titre abrégé: Small Methods
Pays: Germany
ID NLM: 101724536
Informations de publication
Date de publication:
16 Jan 2020
16 Jan 2020
Historique:
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
13
10
2020
Statut:
ppublish
Résumé
Microphysiological systems, also known as organ-on-a-chip platforms, show promise for the development of new testing methods that can be more accurate than both conventional two-dimensional cultures and costly animal studies. The development of more intricate microphysiological systems can help to better mimic the human physiology and highlight the systemic effects of different drugs and materials. Nanomaterials are among a technologically important class of materials used for diagnostic, therapeutic, and monitoring purposes; all of which and can be tested using new organ-on-a-chip systems. In addition, the toxicity of nanomaterials which have entered the body from ambient air or diet can have deleterious effects on various body systems. This in turn can be studied in newly developed microphysiological systems. While organ-on-a-chip models can be useful, they cannot pick up secondary and systemic toxicity. Thus, the utilization of multi-organ-on-a-chip systems for advancing nanotechnology will largely be reflected in the future of drug development, toxicology studies and precision medicine. Various aspects of related studies, current challenges, and future perspectives are discussed in this paper.
Identifiants
pubmed: 33043130
doi: 10.1002/smtd.201900589
pmc: PMC7546538
mid: NIHMS1063364
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCATS NIH HHS
ID : UG3 TR003148
Pays : United States
Références
J Trauma. 1991 May;31(5):629-36; discussion 636-8
pubmed: 2030509
Drug Metab Pharmacokinet. 2018 Feb;33(1):43-48
pubmed: 29175062
J Craniofac Surg. 2018 Oct;29(7):1682-1683
pubmed: 29944567
Sci Rep. 2016 May 06;6:25062
pubmed: 27151082
Lab Chip. 2013 Feb 21;13(4):542-53
pubmed: 23108480
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5688-E5695
pubmed: 29866839
Toxicol Res (Camb). 2018 Aug 11;7(6):1048-1060
pubmed: 30510678
Curr Pharm Des. 2017;23(40):6115-6124
pubmed: 28847303
Biochem Biophys Res Commun. 1991 Mar 29;175(3):880-5
pubmed: 1673839
Lab Chip. 2010 Jan 7;10(1):36-42
pubmed: 20024048
Nat Biotechnol. 2010 Dec;28(12):1300-3
pubmed: 21057497
BMC Cancer. 2017 Nov 2;17(1):709
pubmed: 29096610
J Nanobiotechnology. 2008 Oct 23;6:11
pubmed: 18947410
Sci Rep. 2013 Nov 21;3:3263
pubmed: 24263561
Part Fibre Toxicol. 2005 Oct 06;2:8
pubmed: 16209704
Micromachines (Basel). 2016 Jul 28;7(8):
pubmed: 30404302
Lab Chip. 2008 Aug;8(8):1374-8
pubmed: 18651081
PLoS One. 2015 Oct 21;10(10):e0140506
pubmed: 26488876
Cell Rep. 2017 Oct 10;21(2):508-516
pubmed: 29020635
Nat Biomed Eng. 2017;1:
pubmed: 29038743
Lab Chip. 2013 Sep 21;13(18):3578-87
pubmed: 23743812
Risk Anal. 2015 Jun;35(6):1154-66
pubmed: 25545328
Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5399-5404
pubmed: 30833403
Int J Mol Sci. 2015 Apr 02;16(4):7493-519
pubmed: 25849657
Cell Metab. 2017 Mar 7;25(3):635-646
pubmed: 28273482
Nat Methods. 2011 Jan;8(1):47-51
pubmed: 21191372
Mol Pharm. 2014 Jul 7;11(7):1933-48
pubmed: 24502545
Nature. 2009 Jul 9;460(7252):208-12
pubmed: 19587762
J Tissue Eng Regen Med. 2018 Feb;12(2):479-489
pubmed: 28658717
J Control Release. 2014 Sep 28;190:82-93
pubmed: 24818770
Arch Toxicol. 2006 Mar;80(3):121-4
pubmed: 16411136
Clin J Am Soc Nephrol. 2009 Jul;4(7):1275-83
pubmed: 19520747
Lab Chip. 2018 May 1;18(9):1274-1291
pubmed: 29619452
Lab Chip. 2015 Jun 21;15(12):2688-99
pubmed: 25996126
Lab Chip. 2014 Aug 21;14(16):3081-92
pubmed: 24970651
Biomicrofluidics. 2017 May 09;11(3):031301
pubmed: 28529670
Toxicol In Vitro. 2018 Feb;46:1-8
pubmed: 28986290
Nat Rev Drug Discov. 2015 Apr;14(4):248-60
pubmed: 25792263
Science. 2019 Jun 07;364(6444):960-965
pubmed: 31171693
Gastroenterology. 1989 Mar;96(3):736-49
pubmed: 2914637
Nat Rev Nephrol. 2017 Jan;13(1):39-46
pubmed: 27890924
Drug Metab Dispos. 2004 Sep;32(9):937-42
pubmed: 15319334
Toxicol Appl Pharmacol. 2012 Jan 15;258(2):151-65
pubmed: 22178382
Lab Chip. 2009 Nov 21;9(22):3185-92
pubmed: 19865724
Br Med Bull. 2003;68:167-82
pubmed: 14757716
Trends Cell Biol. 2011 Dec;21(12):745-54
pubmed: 22033488
Drug Discov Today. 2016 Sep;21(9):1399-1411
pubmed: 27422270
Arch Toxicol. 2007 May;81(5):385-7
pubmed: 17262219
Cell Metab. 2015 Nov 3;22(5):886-94
pubmed: 26387866
Biomicrofluidics. 2015 Oct 26;9(5):054124
pubmed: 26576206
Nat Rev Neurosci. 2012 Oct;13(10):701-12
pubmed: 22968153
Lab Chip. 2013 Sep 21;13(18):3538-47
pubmed: 23648632
Lab Chip. 2016 Oct 18;16(21):4097-4105
pubmed: 27722710
Pflugers Arch. 2012 Dec;464(6):601-11
pubmed: 23014881
Drug Discov Today. 2017 Sep;22(9):1392-1399
pubmed: 28390929
Mater Today Bio. 2019 May 25;1:100008
pubmed: 32159140
Curr Drug Targets. 2011 Mar 1;12(3):357-65
pubmed: 20955146
Lab Chip. 2017 Dec 19;18(1):115-125
pubmed: 29184959
Kidney Int. 2013 Apr;83(4):593-603
pubmed: 23389418
FASEB J. 2007 Mar;21(3):790-801
pubmed: 17197384
Integr Biol (Camb). 2013 Sep;5(9):1130-40
pubmed: 23817533
Biotechnol Bioeng. 2016 Oct;113(10):2213-27
pubmed: 27070809
Nat Commun. 2017 Aug 15;8(1):262
pubmed: 28811479
Sci Rep. 2017 Nov 6;7(1):14620
pubmed: 29097671
Lab Chip. 2012 Apr 24;12(10):1784-92
pubmed: 22422217
Mol Microbiol. 1993 Feb;7(3):371-81
pubmed: 8459765
Biomicrofluidics. 2017 Jun 01;11(3):034114
pubmed: 28652884
PLoS One. 2015 Oct 06;10(10):e0139587
pubmed: 26440672
Sci Rep. 2015 Mar 09;5:8883
pubmed: 25748532
ACS Nano. 2017 May 23;11(5):4542-4552
pubmed: 28443337
Clin Nutr. 2009 Dec;28(6):657-61
pubmed: 19523724
Cell Mol Gastroenterol Hepatol. 2018 Apr 24;5(4):659-668
pubmed: 29713674
Nature. 2009 Aug 27;460(7259):1080-1
pubmed: 19713914
Biochem Biophys Res Commun. 2000 Aug 11;274(3):817-20
pubmed: 10924359
Biotechnol Prog. 2007 Sep-Oct;23(5):1245-53
pubmed: 17725364
Sci Rep. 2018 Feb 13;8(1):2871
pubmed: 29440725
Polymers (Basel). 2018 Nov 07;10(11):
pubmed: 30961163
Lab Chip. 2013 Mar 7;13(5):978-85
pubmed: 23340920
Nephrol Dial Transplant. 2004 Sep;19(9):2198-207
pubmed: 15266032
Biofabrication. 2016 Mar 24;8(1):015021
pubmed: 27011358
Biofabrication. 2017 Feb 03;9(1):015014
pubmed: 28155845
Part Fibre Toxicol. 2006 Aug 14;3:11
pubmed: 16907977
Lab Chip. 2012 Jun 21;12(12):2165-74
pubmed: 22434367
Exp Biol Med (Maywood). 2017 Oct;242(16):1573-1578
pubmed: 28343437
Cell Biol Toxicol. 2002;18(5):341-8
pubmed: 12240965
Biofabrication. 2014 Sep;6(3):035001
pubmed: 24722236
Adv Sci (Weinh). 2017 Mar 06;4(5):1600522
pubmed: 28546915
Cell Stem Cell. 2018 Mar 1;22(3):310-324
pubmed: 29499151
Lab Chip. 2018 Dec 18;19(1):9-10
pubmed: 30284573
Lab Chip. 2014 May 21;14(10):1715-24
pubmed: 24663955
Ann N Y Acad Sci. 2014 Apr;1311:14-30
pubmed: 24650218
Kidney Int. 2016 Sep;90(3):627-37
pubmed: 27521113
Exp Cell Res. 2018 Feb 1;363(1):15-25
pubmed: 29291400
ACS Appl Mater Interfaces. 2016 Oct 5;8(39):25840-25847
pubmed: 27606718
J Clin Med Res. 2009 Oct;1(4):191-4
pubmed: 22461867
Lab Chip. 2015 Aug 21;15(16):3326-34
pubmed: 26152353
Biomed Microdevices. 2017 Jun;19(2):22
pubmed: 28374277
Sci Rep. 2017 Aug 18;7(1):8837
pubmed: 28821762
Cell. 2016 May 19;165(5):1238-1254
pubmed: 27118425
J Craniofac Surg. 2019 May/Jun;30(3):623-625
pubmed: 30817536
Lab Chip. 2018 Jan 30;18(3):486-495
pubmed: 29309077
Biotechniques. 2017 Mar 1;62(3):93-98
pubmed: 28298175
Pharmaceutics. 2012 Jan 06;4(1):26-41
pubmed: 24300178
Small. 2017 Apr;13(15):
pubmed: 28211642
Acta Biomater. 2018 Aug;76:154-163
pubmed: 29807185
Cell Metab. 2013 Jan 8;17(1):49-60
pubmed: 23312283
Nat Biotechnol. 2014 Aug;32(8):760-72
pubmed: 25093883
Lab Chip. 2016 Jul 5;16(14):2719-29
pubmed: 27332143
ACS Appl Mater Interfaces. 2015 Sep 9;7(35):19789-97
pubmed: 26280545
Micromachines (Basel). 2018 Oct 22;9(10):
pubmed: 30424469
Lab Chip. 2016 Jul 5;16(14):2618-25
pubmed: 27302471
Nat Rev Neurosci. 2011 Jul 13;12(8):453-66
pubmed: 21750565
J Craniofac Surg. 2018 Jun;29(4):823-824
pubmed: 29750724
Toxicol Res (Camb). 2017 Apr 25;6(3):372-380
pubmed: 30090506
Chem Biol Interact. 2004 Nov 1;150(1):129-36
pubmed: 15522266
Integr Biol (Camb). 2013 Sep;5(9):1119-29
pubmed: 23644926
Nature. 2006 Jul 27;442(7101):368-73
pubmed: 16871203
Development. 2018 May 18;145(16):
pubmed: 29776965
Sci Rep. 2016 Oct 11;6:34845
pubmed: 27725720
Lab Chip. 2013 Jul 7;13(13):2591-8
pubmed: 23525275
JCI Insight. 2017 Nov 16;2(22):
pubmed: 29202460
Lab Chip. 2016 Apr 26;16(9):1579-86
pubmed: 26999423
Lab Chip. 2003 Aug;3(3):193-7
pubmed: 15100773
Kidney Int. 2018 Dec;94(6):1073-1086
pubmed: 30366681
Adv Mater. 2019 Jan;31(1):e1804041
pubmed: 30565732
Environ Health Perspect. 2005 Jul;113(7):823-39
pubmed: 16002369
J Biomed Mater Res B Appl Biomater. 2019 Aug;107(6):2006-2018
pubmed: 30597720
IEEE Trans Biomed Eng. 2013 Mar;60(3):682-90
pubmed: 23380852
Theranostics. 2013;3(3):152-66
pubmed: 23471164
J Pharmacol Toxicol Methods. 2009 Sep-Oct;60(2):152-8
pubmed: 19616110
Exp Biol Med (Maywood). 2017 Nov;242(17):1657-1668
pubmed: 28592171
J Matern Fetal Neonatal Med. 2016;29(7):1046-54
pubmed: 26075842
Lab Chip. 2013 Sep 21;13(18):3496-511
pubmed: 23828456
Nat Med. 2014 Oct;20(10):1211-6
pubmed: 25216635
Vet Pathol. 2012 Mar;49(2):344-56
pubmed: 21441112
Nature. 2011 Apr 7;472(7341):57-63
pubmed: 21475195
Am Fam Physician. 2008 Sep 15;78(6):743-50
pubmed: 18819242
J Am Soc Nephrol. 2016 Apr;27(4):1015-28
pubmed: 26260164
Sci Rep. 2015 Jul 02;5:11800
pubmed: 26135970
EBioMedicine. 2018 Jan;27:225-236
pubmed: 29289530
Drug Metab Pharmacokinet. 2011;26(1):3-14
pubmed: 20978361
Methods Mol Biol. 2017;1612:345-365
pubmed: 28634955
J Biotechnol. 2015 Dec 20;216:1-10
pubmed: 26435219
Nat Rev Drug Discov. 2016 Jul;15(7):457-71
pubmed: 26893184
Stem Cell Rev Rep. 2017 Jun;13(3):335-346
pubmed: 28429185
Biotechnol Bioeng. 2012 Mar;109(3):797-803
pubmed: 22012446
Anal Chem. 2011 Nov 15;83(22):8377-82
pubmed: 22032307
Bioengineering (Basel). 2018 Jun 07;5(2):
pubmed: 29880746
PLoS One. 2016 Jul 20;11(7):e0159729
pubmed: 27438262
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3296-300
pubmed: 15728383
Lab Chip. 2016 Apr 7;16(7):1106-25
pubmed: 26923141
Analyst. 2014 Mar 7;139(5):906-13
pubmed: 24300894
Microvasc Res. 2015 Jan;97:147-55
pubmed: 25446009
Biotechnol Bioeng. 2009 Sep 1;104(1):193-205
pubmed: 19418562
Science. 2010 Jun 25;328(5986):1662-8
pubmed: 20576885
Nat Med. 2013 May;19(5):576-85
pubmed: 23563705
Nat Med. 2014 Jun;20(6):616-23
pubmed: 24813252
Nanomedicine (Lond). 2019 Aug;14(16):2209-2226
pubmed: 31179822
J Lab Autom. 2015 Jun;20(3):265-73
pubmed: 25385717
Anal Bioanal Chem. 2018 Sep;410(24):6141-6154
pubmed: 29744562
Int J Artif Organs. 2008 Jun;31(6):508-14
pubmed: 18609503
N Engl J Med. 2013 Apr 25;368(17):1575-84
pubmed: 23614584
Int J Food Microbiol. 2009 Jul 31;133(1-2):86-93
pubmed: 19523707
Nat Mater. 2017 Mar;16(3):303-308
pubmed: 27775708
Lab Chip. 2013 Sep 21;13(18):3555-61
pubmed: 23674126