Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin.
Biomedical engineering
Biotechnology
Materials application
Materials characterization
Pharmaceutical science
Poly-ion complex
Polyamine
Sustained release of heparin
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
09
05
2020
revised:
04
08
2020
accepted:
01
10
2020
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
13
10
2020
Statut:
ppublish
Résumé
Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion complex (PIC). PIC formation (or stability) was influenced by the concentration and ratio of heparin and polyamines, molecular weight of heparin, nature of polyamines, and pH conditions. Interestingly, the PIC obtained when heparin and tetrakis (3-aminopropyl) ammonium (Taa) were mixed exhibited stability and was sticky in nature. PIC formation was due to an electrostatic interaction between heparin and Taa. Heparin-Taa PIC was administered subcutaneously to mice, and the time to maximum heparin concentration within the therapeutic range of heparin was markedly increased compared to that after a single dose of heparin. These results suggest that the quaternary ammonium structure of Taa is critical for the preparation of a stable PIC, thereby allowing the sustained release of heparin into the blood.
Identifiants
pubmed: 33043161
doi: 10.1016/j.heliyon.2020.e05168
pii: S2405-8440(20)32011-9
pmc: PMC7538075
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e05168Informations de copyright
© 2020 The Author(s).
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