A phase 2, open label, multicenter, single arm study of tocilizumab on the efficacy and tolerability of tocilizumab in the treatment of patients with COVID-19 pneumonia (TOCIVID-19 trial): Statistical analysis plan.

COVID-19 pneumonia Phase 2 trial Statistical analysis plan Tocilizumab

Journal

Contemporary clinical trials communications
ISSN: 2451-8654
Titre abrégé: Contemp Clin Trials Commun
Pays: Netherlands
ID NLM: 101671157

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 28 05 2020
revised: 04 09 2020
accepted: 03 10 2020
entrez: 12 10 2020
pubmed: 13 10 2020
medline: 13 10 2020
Statut: ppublish

Résumé

Tocilizumab, an IL-6 receptor antagonist, was suggested as a possible treatment of severe or critical COVID-19 pneumonia in a small Chinese study. The TOCIVID-19 trial evaluates efficacy and tolerability of tocilizumab in the treatment of patients with severe or critical COVID-19 pneumonia. TOCIVID-19 is an academic multicenter, single-arm, open-label, phase 2 study. All the patients are being offered a single shot of 8 mg/kg of Tocilizumab (up to a maximum of 800 mg), with an eventual second administration at the discretion of the Investigator. A companion prospective cohort, added to corroborate internal validity, includes either patients not eligible for phase 2 or subjects eligible for phase 2 but exceeding the planned sample size. 14- and 30-days lethality rates are the two co-primary endpoints in the intention-to-treat (ITT) population. Secondary objectives are to evaluate mortality and clinical improvement in the modified-ITT population of subjects who received the drug. Details of the methodological and statistical approaches are reported here reflecting the amendments impelled by the continuously increasing knowledge on COVID-19 progression and challenges in data collection. This paper provides details of planned statistical analyses for TOCIVID19 trial to reduce the risk of reporting bias and increase validity of the study findings.TOCIVID-19 trial is registered in the EudraCT database with number 2020-001110-38 and in clinicaltrials.gov with ID NCT04317092.

Sections du résumé

BACKGROUND BACKGROUND
Tocilizumab, an IL-6 receptor antagonist, was suggested as a possible treatment of severe or critical COVID-19 pneumonia in a small Chinese study. The TOCIVID-19 trial evaluates efficacy and tolerability of tocilizumab in the treatment of patients with severe or critical COVID-19 pneumonia.
METHODS METHODS
TOCIVID-19 is an academic multicenter, single-arm, open-label, phase 2 study. All the patients are being offered a single shot of 8 mg/kg of Tocilizumab (up to a maximum of 800 mg), with an eventual second administration at the discretion of the Investigator. A companion prospective cohort, added to corroborate internal validity, includes either patients not eligible for phase 2 or subjects eligible for phase 2 but exceeding the planned sample size. 14- and 30-days lethality rates are the two co-primary endpoints in the intention-to-treat (ITT) population. Secondary objectives are to evaluate mortality and clinical improvement in the modified-ITT population of subjects who received the drug. Details of the methodological and statistical approaches are reported here reflecting the amendments impelled by the continuously increasing knowledge on COVID-19 progression and challenges in data collection.
CONCLUSION CONCLUSIONS
This paper provides details of planned statistical analyses for TOCIVID19 trial to reduce the risk of reporting bias and increase validity of the study findings.TOCIVID-19 trial is registered in the EudraCT database with number 2020-001110-38 and in clinicaltrials.gov with ID NCT04317092.

Identifiants

pubmed: 33043164
doi: 10.1016/j.conctc.2020.100665
pii: S2451-8654(20)30149-6
pmc: PMC7538865
doi:

Banques de données

ClinicalTrials.gov
['NCT04317092']

Types de publication

Journal Article

Langues

eng

Pagination

100665

Informations de copyright

© 2020 The Authors.

Déclaration de conflit d'intérêts

PC, LA and CG have no competing interests. FP and MCP coordinate three academic clinical trials in oncology, promoted by the Istituto Nazionale Tumori di Napoli, that are supported by Roche (clilnicaltrials.gov id: NCT01706120, NCT01802749, NCT02633189).

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Auteurs

Paolo Chiodini (P)

Medical Statistics Unit, University of Campania 'Luigi Vanvitelli', Napoli, Italy.

Laura Arenare (L)

Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.

Maria Carmela Piccirillo (MC)

Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.

Francesco Perrone (F)

Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.

Ciro Gallo (C)

Medical Statistics Unit, University of Campania 'Luigi Vanvitelli', Napoli, Italy.

Classifications MeSH