SAXS reveals highly flexible interdomain linkers of tandem acyl carrier protein-thioesterase domains from a fungal nonreducing polyketide synthase.
acyl carrier protein
fungal nonreducing polyketide synthase
macrocyclic polylactone
small-angle X-ray scattering
thioesterase
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
28
05
2020
revised:
01
10
2020
accepted:
05
10
2020
pubmed:
13
10
2020
medline:
8
7
2021
entrez:
12
10
2020
Statut:
ppublish
Résumé
Menisporopsin A is a fungal bioactive macrocyclic polylactone, the biosynthesis of which requires only reducing (R) and nonreducing (NR) polyketide synthases (PKSs) to guide a series of esterification and cyclolactonization reactions. There is no structural information pertaining to these PKSs. Here, we report the solution characterization of singlet and doublet acyl carrier protein (ACP
Identifiants
pubmed: 33043457
doi: 10.1002/1873-3468.13954
doi:
Substances chimiques
Acyl Carrier Protein
0
Macrolides
0
menisporopsin A
0
Polyketide Synthases
79956-01-7
Thiolester Hydrolases
EC 3.1.2.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-144Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L01386X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/T001968/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/OS/GC/000004
Pays : United Kingdom
Informations de copyright
© 2020 Federation of European Biochemical Societies.
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