Functional diversity of cancer-associated fibroblasts in modulating drug resistance.
cancer stemness
cancer‐associated fibroblast
chemoresistance
immunotherapy
metabolic modulation
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
17
04
2020
revised:
14
07
2020
accepted:
16
07
2020
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
21
10
2020
Statut:
ppublish
Résumé
The effectiveness of current chemotherapies for cancer is gradually progressing; however achieving a complete cure through chemotherapy is still difficult and has been the main goal in treatment of advanced cancer. Drug resistance is an issue in cancer therapy, therefore increasing numbers of investigations into drug resistance have focused on the characteristics of the cancer cells themselves. The interaction between the tumor microenvironment (TME) and cancer cells is also intimately involved in the development of drug resistance. Cancer-associated fibroblasts (CAFs) are a predominant component of the TME and affect tumor progression by secreting soluble factors. This review summarizes the most up-to-date knowledge of CAFs and drug resistance in cancer, with a focus on factors secreted from CAFs including proteins, cytokines, extracellular vesicles, and metabolites. A perspective on the potential role of anti-CAF therapies in overcoming CAF-induced drug resistance is also discussed.
Identifiants
pubmed: 33044028
doi: 10.1111/cas.14578
pmc: PMC7541012
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3468-3477Subventions
Organisme : Japan Society for the Promotion of Science
ID : 20H03531
Organisme : Uehara Memorial Foundation
Informations de copyright
© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
Références
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7551-6
pubmed: 27317748
Cancer Discov. 2019 Feb;9(2):282-301
pubmed: 30366930
Immunity. 2009 Jul 17;31(1):131-44
pubmed: 19604492
Oncogene. 2004 Jul 15;23(32):5435-46
pubmed: 15133496
J Cell Mol Med. 2011 Mar;15(3):635-46
pubmed: 20184663
Oncogene. 2017 Aug;36(31):4457-4468
pubmed: 28368410
Cancer Res. 2007 Nov 1;67(21):10123-8
pubmed: 17974953
Cancer Res. 2017 Apr 15;77(8):2134-2147
pubmed: 28202523
Cancer Lett. 2018 May 1;421:121-126
pubmed: 29331418
Cell Death Dis. 2017 Jun 1;8(6):e2848
pubmed: 28569790
Cancer Cell. 2014 Jun 16;25(6):719-34
pubmed: 24856586
Pharmacol Ther. 2016 Apr;160:145-58
pubmed: 26899500
Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5990-E5999
pubmed: 29891662
Nature. 2012 Jul 26;487(7408):500-4
pubmed: 22763439
Cancer Res. 2004 Dec 1;64(23):8492-5
pubmed: 15574751
Nat Med. 2012 Sep;18(9):1359-68
pubmed: 22863786
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20212-7
pubmed: 24277834
Science. 2009 Jun 12;324(5933):1457-61
pubmed: 19460966
Sci Rep. 2015 Jul 08;5:11924
pubmed: 26152796
Gut. 2006 Jan;55(1):79-89
pubmed: 16043492
Cancer Cell. 2005 Nov;8(5):369-80
pubmed: 16286245
Cancer Cell. 2014 Jun 16;25(6):735-47
pubmed: 24856585
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20009-14
pubmed: 21041659
Int J Cancer. 2004 Nov 1;112(2):213-8
pubmed: 15352032
PLoS One. 2015 May 04;10(5):e0125625
pubmed: 25938772
Nat Med. 2013 Nov;19(11):1423-37
pubmed: 24202395
Cancer Res. 2018 Jul 1;78(13):3445-3457
pubmed: 29760045
J Exp Med. 2017 Mar 6;214(3):579-596
pubmed: 28232471
Nat Rev Clin Oncol. 2017 Jul;14(7):399-416
pubmed: 28117416
Oncogene. 2019 Mar;38(11):1951-1965
pubmed: 30390075
Cell. 2018 Feb 8;172(4):841-856.e16
pubmed: 29395328
Cell Stem Cell. 2011 Sep 2;9(3):262-71
pubmed: 21885021
Cancer Discov. 2019 Aug;9(8):1102-1123
pubmed: 31197017
Theranostics. 2018 Jun 24;8(14):3932-3948
pubmed: 30083271
PLoS One. 2009 Nov 23;4(11):e7965
pubmed: 19956757
Nat Genet. 2015 Apr;47(4):320-9
pubmed: 25706628
Stem Cells. 2017 Sep;35(9):2027-2036
pubmed: 28699179
Fibrogenesis Tissue Repair. 2012 Jun 06;5(Suppl 1):S5
pubmed: 23259712
Oncogene. 2016 Aug 18;35(33):4321-34
pubmed: 26751775
Oncogene. 2017 Apr;36(15):2131-2145
pubmed: 27721408
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4120-5
pubmed: 12646700
Cancer Cell. 2018 Mar 12;33(3):463-479.e10
pubmed: 29455927
Tumour Biol. 2016 Jul;37(7):9045-57
pubmed: 26762409
J Exp Med. 2013 Dec 16;210(13):2851-72
pubmed: 24323355
Nature. 2018 Feb 22;554(7693):538-543
pubmed: 29443964
Nat Cell Biol. 2010 May;12(5):468-76
pubmed: 20418870
Int J Cancer. 2016 Mar 1;138(5):1207-19
pubmed: 26414794
Proteomics. 2013 Jan;13(2):379-88
pubmed: 23175172
Mol Cancer. 2019 Mar 30;18(1):68
pubmed: 30927911
Oncogene. 2019 Jun;38(25):4887-4901
pubmed: 30816343
Cancer Res. 2013 Sep 15;73(18):5657-68
pubmed: 23903958
Cancer Lett. 2012 May 28;318(2):154-61
pubmed: 22182446
J Clin Invest. 2018 Oct 1;128(10):4472-4484
pubmed: 30047926
PLoS One. 2017 Jul 27;12(7):e0182039
pubmed: 28750018
Gastroenterology. 2017 Jul;153(1):191-204.e16
pubmed: 28390866
Nat Rev Cancer. 2016 Aug 23;16(9):582-98
pubmed: 27550820
Cancer Res. 2020 Aug 15;80(16):3222-3235
pubmed: 32605995
Cell. 2019 Jun 27;178(1):160-175.e27
pubmed: 31155233
Oncogene. 2018 Feb 15;37(7):873-883
pubmed: 29059160
Cancer Cell. 2011 Mar 8;19(3):387-400
pubmed: 21397861
J Clin Invest. 2003 Dec;112(12):1776-84
pubmed: 14679171
Gut. 2020 Feb;69(2):243-251
pubmed: 31085554
J Exp Med. 2005 Mar 21;201(6):925-35
pubmed: 15781583
Oncogenesis. 2018 Oct 5;7(10):78
pubmed: 30287850
Cancer Lett. 2019 Jul 10;454:37-43
pubmed: 30978440
Breast Cancer Res Treat. 2012 Oct;135(3):737-47
pubmed: 22923236
Clin Cancer Res. 2017 Apr 1;23(7):1710-1721
pubmed: 27702820
J Clin Invest. 2002 Aug;110(3):341-50
pubmed: 12163453
Nature. 2020 Apr;580(7804):524-529
pubmed: 32322056
Cancer Res. 2017 Apr 15;77(8):1927-1941
pubmed: 28202520
J Cell Biol. 1995 Jul;130(2):393-405
pubmed: 7615639
Nat Commun. 2013;4:1795
pubmed: 23653207
Nat Commun. 2018 Nov 8;9(1):4692
pubmed: 30410077
Cancer Cell. 2015 Apr 13;27(4):574-88
pubmed: 25873177
Cancer Cell. 2011 Feb 15;19(2):257-72
pubmed: 21316604
Cell Metab. 2018 Dec 4;28(6):848-865.e6
pubmed: 30174307
Cancer Res. 2018 Apr 1;78(7):1700-1712
pubmed: 29363544
Cell Metab. 2016 Nov 8;24(5):685-700
pubmed: 27829138
Curr Opin Pharmacol. 2017 Aug;35:1-11
pubmed: 28527911
Cancer Res. 2019 Oct 15;79(20):5367-5381
pubmed: 31439548