Landscape of coordinated immune responses to H1N1 challenge in humans.
Adaptive immunity
Immunology
Infectious disease
Influenza
Innate immunity
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
02 11 2020
02 11 2020
Historique:
received:
17
02
2020
accepted:
31
07
2020
pubmed:
13
10
2020
medline:
17
2
2021
entrez:
12
10
2020
Statut:
ppublish
Résumé
Influenza is a significant cause of morbidity and mortality worldwide. Here we show changes in the abundance and activation states of more than 50 immune cell subsets in 35 individuals over 11 time points during human A/California/2009 (H1N1) virus challenge monitored using mass cytometry along with other clinical assessments. Peak change in monocyte, B cell, and T cell subset frequencies coincided with peak virus shedding, followed by marked activation of T and NK cells. Results led to the identification of CD38 as a critical regulator of plasmacytoid dendritic cell function in response to influenza virus. Machine learning using study-derived clinical parameters and single-cell data effectively classified and predicted susceptibility to infection. The coordinated immune cell dynamics defined in this study provide a framework for identifying novel correlates of protection in the evaluation of future influenza therapeutics.
Identifiants
pubmed: 33044226
pii: 137265
doi: 10.1172/JCI137265
pmc: PMC7598057
doi:
pii:
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5800-5816Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM137936
Pays : United States
Organisme : NIDDK NIH HHS
ID : UG3 DK114937
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108686
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI100627
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120724
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI101984
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG010426
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA212231
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400005C
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA183692
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135976
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM109836
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA183654
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057229
Pays : United States
Organisme : NCI NIH HHS
ID : U2C CA233238
Pays : United States
Organisme : Cancer Research UK
ID : C27165/A29073
Pays : United Kingdom
Organisme : CIHR
Pays : Canada
Organisme : NIAID NIH HHS
ID : U01 AI140498
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA209971
Pays : United States
Organisme : NIGMS NIH HHS
ID : K23 GM111657
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA233203
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL108797
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM138353
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI113047
Pays : United States
Organisme : NCI NIH HHS
ID : U2C CA233195
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA196657
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128173
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067676
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131374
Pays : United States
Organisme : NIAMS NIH HHS
ID : DP2 AR069953
Pays : United States
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