Evaluation of myostatin as a possible regulator and marker of skeletal muscle-cortical bone interaction in adults.
Bone–muscle relationship
Cortical bone
Myostatin
Skeletal muscle mass
Journal
Journal of bone and mineral metabolism
ISSN: 1435-5604
Titre abrégé: J Bone Miner Metab
Pays: Japan
ID NLM: 9436705
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
04
05
2020
accepted:
21
09
2020
pubmed:
13
10
2020
medline:
15
5
2021
entrez:
12
10
2020
Statut:
ppublish
Résumé
Bone mass was recently reported to be related to skeletal muscle mass in humans, and a decrease in cortical bone is a risk factor for osteoporosis. Because circulating myostatin is a factor that primarily controls muscle metabolism, this study examined the role of myostatin in bone mass-skeletal muscle mass interactions. The subjects were 375 middle-aged community residents with no history of osteoporosis or sarcopenia who participated in a health check-up. Cortical bone thickness and cancellous bone density were measured by ultrasonic bone densitometry in a health check-up survey. The subjects were divided into those with low cortical bone thickness (LCT) or low cancellous bone density (LBD) and those with normal values (NCT/NBD). Bone metabolism markers (TRACP-5b, etc.), skeletal muscle mass, serum myostatin levels, and lifestyle were then compared between the groups. The percentage of diabetic participants, TRACP-5b, and myostatin levels were significantly higher, and the frequency of physical activity, skeletal muscle mass, grip strength, and leg strength were significantly lower in the LCT group than in the NCT group. The odds ratio (OR) of high myostatin levels in the LCT group compared with the NCT group was significant (OR 2.17) even after adjusting for related factors. Between the low cancellous bone density (LBD) and normal cancellous bone density (NBD) groups, significant differences were observed in the same items as between the LCT and NCT groups, but no significant differences were observed in skeletal muscle mass and blood myostatin levels. The myostatin level was significantly negatively correlated with cortical bone thickness and skeletal muscle mass. A decrease in cortical bone thickness was associated with a decrease in skeletal muscle mass accompanied by an increase in the blood myostatin level. Blood myostatin may regulate the bone-skeletal muscle relationship and serve as a surrogate marker of bone metabolism, potentially linking muscle mass to bone structure.
Identifiants
pubmed: 33044569
doi: 10.1007/s00774-020-01160-8
pii: 10.1007/s00774-020-01160-8
doi:
Substances chimiques
Biomarkers
0
Myostatin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
404-415Subventions
Organisme : the Ministry of Education, Science, Sports, and Culture of Japan.
ID : Grant-in-Aid for Scientific Research (B) (No. 18H03052)
Organisme : the Ministry of Education, Science, Sports, and Culture of Japan.
ID : Grant-in-Aid for Scientific Research (C) (No. 15K08812)
Organisme : Grants-in-Aid for Scientific Research on Priority Areas
ID : No. 17015018
Organisme : Platform of Supporting Cohort Study and Biospecimen Analysis
ID : No. 221S0001
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