Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain.

Animals Brain / metabolism Female Gene Silencing Male Neuropeptide Y / genetics Receptors, Neuropeptide Y / genetics Sex Characteristics
Cognitive and emotional behavior Energy homeostasis Knockout animal Neuropeptide Y Sex differences Transgenic animal Y receptors

Journal

Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090

Informations de publication

Date de publication:
12 2020
Historique:
received: 10 03 2020
revised: 16 09 2020
accepted: 17 09 2020
pubmed: 13 10 2020
medline: 22 6 2021
entrez: 12 10 2020
Statut: ppublish

Résumé

Brain and gonadal hormones interplay controls metabolic and behavioral functions in a sex-related manner. However, most translational neuroscience research related to animal models of endocrine and psychiatric disorders are often carried out in male animals only. The Neuropeptide Y (NPY) system shows sex-dependent differences and is sensitive to gonadal steroids. Based on published data from our and other laboratories, in this review we will discuss the sex related differences of NPY action on energy balance, bone homeostasis and behavior in rodents with the genetic manipulation of genes encoding NPY and its Y1, Y2 and Y5 cognate receptors. Comparative analyses of the phenotype of transgenic and knockout NPY and Y receptor rodents unravels sex dependent differences in the functions of this neurotransmission system, potentially helping to develop therapeutics for a variety of sex-related disorders including metabolic syndrome, osteoporosis and ethanol addiction.

Identifiants

DOI: 10.1016/j.neubiorev.2020.09.020 PMID: 33045245
pubmed: 33045245
pii: S0149-7634(20)30577-7
doi: 10.1016/j.neubiorev.2020.09.020
pii:
doi:

Substances chimiques

Neuropeptide Y 0
Receptors, Neuropeptide Y 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

333-347

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Carola Eva (C)

Neuroscience Institute of the Cavalieri-Ottolenghi Foundation, 10043 Orbassano, Turin, Italy; Department of Neuroscience, University of Turin, 10126 Turin, Italy; Neuroscience Institute of Turin, University of Parma, 43100, Parma, Italy. Electronic address: carola.eva@unito.it.

Alessandra Oberto (A)

Neuroscience Institute of the Cavalieri-Ottolenghi Foundation, 10043 Orbassano, Turin, Italy; Department of Neuroscience, University of Turin, 10126 Turin, Italy; Neuroscience Institute of Turin, University of Parma, 43100, Parma, Italy.

Angela Longo (A)

Neuroscience Institute of the Cavalieri-Ottolenghi Foundation, 10043 Orbassano, Turin, Italy; Department of Neuroscience, University of Turin, 10126 Turin, Italy.

Paola Palanza (P)

Department of Medicine and Surgery, University of Parma, 43100, Parma, Italy.

Ilaria Bertocchi (I)

Neuroscience Institute of the Cavalieri-Ottolenghi Foundation, 10043 Orbassano, Turin, Italy; Department of Neuroscience, University of Turin, 10126 Turin, Italy; Neuroscience Institute of Turin, University of Parma, 43100, Parma, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Sex differences in behavioral and metabolic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Sex differences in behavioral and metabolic...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Sex differences in behavioral and metabolic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Neuropeptide Y › Sex differences in behavioral and metabolic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteur neuropeptide Y › Sex differences in behavioral and metabolic...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Sex differences in behavioral and metabolic...