The Cryo-immunologic effect: A therapeutic advance in the treatment of glioblastomas?
Brain Oncology
Brain tumors
Cryotherapy
Cryothérapie
Imagerie guidée par IRM
Immunotherapie
Immunotherapy
MRI imaging guided
Oncologie cérébrale
Tumeurs cérébrales
Journal
Neuro-Chirurgie
ISSN: 1773-0619
Titre abrégé: Neurochirurgie
Pays: France
ID NLM: 0401057
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
26
02
2020
revised:
15
04
2020
accepted:
28
06
2020
pubmed:
13
10
2020
medline:
23
6
2021
entrez:
12
10
2020
Statut:
ppublish
Résumé
The immunotherapy of cerebral glioblastoma has become a hot topic. Immune checkpoint blockade antibodies have progressively acquired a role in the management of malignant tumors. A multimodal approach using surgery, radiotherapy, chemotherapy in combination with immunotherapy represent a potent weapon against glioblastomas. In parallel, clinical applications of cryotherapy-freezing tumors based on repetition of rapid freeze-slow thaw cycle-for various cancers such as skin, lung, breast, esophagus, hepatic, kidney, prostate and bone tumors were developed. The future immunomodulatory approaches might be combined with brain tumors cryoablation to increase the cryoimmune response. The objective of this study was to analyze from the literature the relationship between cerebral cryosurgery and immunomodulation using PRISMA method. The animals' studies demonstrate the dendritic cells maturation and activation with the enhancement of antigen-presenting function after cryotherapy suggesting the potential usefulness of the association of cryotherapy and immunomodulator in the management of gliomas.
Identifiants
pubmed: 33045247
pii: S0028-3770(20)30398-2
doi: 10.1016/j.neuchi.2020.06.135
pii:
doi:
Substances chimiques
Immune Checkpoint Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-460Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.