Cortical thinning in preschoolers with maladaptive guilt.
Brain development
Cortical thickness
MRI
Self-conscious emotion
dmPFC
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 11 2020
30 11 2020
Historique:
received:
13
08
2019
revised:
13
09
2020
accepted:
15
09
2020
pubmed:
13
10
2020
medline:
1
3
2022
entrez:
12
10
2020
Statut:
ppublish
Résumé
Maladaptive guilt is a central symptom of preschool-onset depression associated with severe psychopathology in adolescence and adulthood. Although studies have found that maladaptive guilt is associated with structural alterations in the anterior insula (AI) and dorsomedial prefrontal cortex (dmPFC) in middle childhood and adolescence, no study has examined structural neural correlates of maladaptive guilt in preschool, when this symptom first emerges. This study examined a pooled sample of 3-to 6-year-old children (N = 76; 40.8% female) from two studies, both which used the same type of magnetic resonance imaging scanner and conducted diagnostic interviews for depression that included clinician ratings of whether children met criteria for maladaptive guilt. Preschoolers with maladaptive guilt displayed significantly thinner dmPFC than children without this symptom. Neither children's depressive severity nor their vegetative or other emotional symptoms of depression were associated with dmPFC thickness, suggesting that dmPFC thinning is specific to maladaptive guilt. Neither AI gray matter volume or thickness nor dmPFC gray matter volume differed between children with and without maladaptive guilt. This study is the first to identify a structural biomarker for a specific depressive symptom in preschool. Findings may inform neurobiological models of the development of depression and aid in detection of this symptom.
Identifiants
pubmed: 33045581
pii: S0925-4927(20)30167-0
doi: 10.1016/j.pscychresns.2020.111195
pmc: PMC9245198
mid: NIHMS1780424
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111195Subventions
Organisme : NIMH NIH HHS
ID : R01 MH098454
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH100019
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Références
Neuroimage. 2010 Oct 15;53(1):1-15
pubmed: 20547229
Neurosci Biobehav Rev. 2016 Dec;71:455-471
pubmed: 27687818
J Consult Clin Psychol. 1986 Aug;54(4):528-36
pubmed: 3745607
Am J Psychiatry. 2002 Nov;159(11):1855-61
pubmed: 12411219
Am J Psychiatry. 2018 Nov 1;175(11):1102-1110
pubmed: 29921144
J Affect Disord. 2018 Aug 1;235:135-141
pubmed: 29655075
J Affect Disord. 2012 Apr;138(1-2):9-18
pubmed: 21511342
J Am Acad Child Adolesc Psychiatry. 2004 Jun;43(6):708-17
pubmed: 15167087
Neuroimage. 2010 Dec;53(4):1181-96
pubmed: 20637289
Child Psychiatry Hum Dev. 2008 Jun;39(2):111-22
pubmed: 17710538
J Affect Disord. 2010 Mar;121(3):231-8
pubmed: 19540599
PLoS One. 2014 Jul 22;9(7):e102692
pubmed: 25051163
Neurosci Biobehav Rev. 2016 Jan;60:43-50
pubmed: 26592799
Child Dev. 2002 Mar-Apr;73(2):461-82
pubmed: 11949903
Nat Neurosci. 1999 Oct;2(10):861-3
pubmed: 10491603
Brain Imaging Behav. 2017 Aug;11(4):1164-1178
pubmed: 27704409
JAMA Psychiatry. 2016 Jan;73(1):31-8
pubmed: 26676835
J Affect Disord. 2009 Jan;112(1-3):111-9
pubmed: 18486234
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Clin Child Fam Psychol Rev. 2014 Mar;17(1):19-40
pubmed: 23712881
Dev Psychol. 2019 Oct;55(10):2102-2113
pubmed: 31343231
J Child Psychol Psychiatry. 2009 Sep;50(9):1156-66
pubmed: 19490311
Dev Cogn Neurosci. 2016 Jun;19:51-7
pubmed: 26895352
Nebr Symp Motiv. 1988;36:183-258
pubmed: 3078936
Cereb Cortex. 2017 Feb 1;27(2):1472-1481
pubmed: 28365755
Neurosci Biobehav Rev. 2014 May;42:9-34
pubmed: 24486722
J Affect Disord. 2014 May;160:74-9
pubmed: 24445133
JAMA Psychiatry. 2015 Jan;72(1):40-8
pubmed: 25390502
Neurosci Biobehav Rev. 2011 Jan;35(3):903-11
pubmed: 20974173
J Psychiatr Res. 2009 Apr;43(7):680-6
pubmed: 19000625
Cereb Cortex. 2014 Nov;24(11):2941-50
pubmed: 23749874
Psychol Sci. 2006 Jan;17(1):74-81
pubmed: 16371147
J Am Acad Child Adolesc Psychiatry. 2013 Jul;52(7):737-46
pubmed: 23800487
Dev Cogn Neurosci. 2014 Jul;9:172-90
pubmed: 24879112