Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK.
Bile acid sequestrants
Covid-19
Ezetimibe
Fibrates
Hyperlipidaemia
Lipid lowering therapy
Lomitapide
Omega-3-fatty acids
PCSK9 monoclonal antibodies
Statins
Volanesorsen
Journal
Atherosclerosis
ISSN: 1879-1484
Titre abrégé: Atherosclerosis
Pays: Ireland
ID NLM: 0242543
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
28
05
2020
revised:
02
09
2020
accepted:
08
09
2020
pubmed:
13
10
2020
medline:
27
11
2020
entrez:
12
10
2020
Statut:
ppublish
Résumé
The emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes Coronavirus Disease 2019 (COVID-19) has resulted in a pandemic. SARS-CoV-2 is highly contagious and its severity highly variable. The fatality rate is unpredictable but is amplified by several factors including advancing age, atherosclerotic cardiovascular disease, diabetes mellitus, hypertension and obesity. A large proportion of patients with these conditions are treated with lipid lowering medication and questions regarding the safety of continuing lipid-lowering medication in patients infected with COVID-19 have arisen. Some have suggested they may exacerbate their condition. It is important to consider known interactions with lipid-lowering agents and with specific therapies for COVID-19. This statement aims to collate current evidence surrounding the safety of lipid-lowering medications in patients who have COVID-19. We offer a consensus view based on current knowledge and we rated the strength and level of evidence for these recommendations. Pubmed, Google scholar and Web of Science were searched extensively for articles using search terms: SARS-CoV-2, COVID-19, coronavirus, Lipids, Statin, Fibrates, Ezetimibe, PCSK9 monoclonal antibodies, nicotinic acid, bile acid sequestrants, nutraceuticals, red yeast rice, Omega-3-Fatty acids, Lomitapide, hypercholesterolaemia, dyslipidaemia and Volanesorsen. There is no evidence currently that lipid lowering therapy is unsafe in patients with COVID-19 infection. Lipid-lowering therapy should not be interrupted because of the pandemic or in patients at increased risk of COVID-19 infection. In patients with confirmed COVID-19, care should be taken to avoid drug interactions, between lipid-lowering medications and drugs that may be used to treat COVID-19, especially in patients with abnormalities in liver function tests.
Identifiants
pubmed: 33045618
pii: S0021-9150(20)30504-9
doi: 10.1016/j.atherosclerosis.2020.09.008
pmc: PMC7490256
pii:
doi:
Substances chimiques
Hypolipidemic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
126-136Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Références
J Am Heart Assoc. 2015 Sep 15;4(9):e001508
pubmed: 26374297
J Am Coll Cardiol. 2018 Jul 3;72(1):96-118
pubmed: 29957236
Biol Psychiatry. 2014 Oct 1;76(7):559-66
pubmed: 24602409
Clin Pharmacokinet. 1998 Feb;34(2):155-62
pubmed: 9515185
Biochem Biophys Res Commun. 1999 Apr 2;257(1):79-83
pubmed: 10092513
Cardiovasc Res. 2000 Sep;47(4):648-57
pubmed: 10974215
Expert Opin Drug Saf. 2019 Dec;18(12):1191-1201
pubmed: 31623472
Clin Pharmacol Ther. 2011 May;89(5):735-40
pubmed: 21430660
N Engl J Med. 2020 Jun 18;382(25):2441-2448
pubmed: 32356628
Clin Cardiol. 2019 Jun;42(6):618-628
pubmed: 30993750
Crit Rev Oncol Hematol. 2017 Jun;114:1-12
pubmed: 28477737
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
Curr Vasc Pharmacol. 2016;14(3):280-7
pubmed: 26733388
Ann Hematol. 2020 Jun;99(6):1205-1208
pubmed: 32296910
Br J Clin Pharmacol. 2015 Aug;80(2):179-81
pubmed: 25702706
J Cell Physiol. 2018 Apr;233(4):2920-2927
pubmed: 28574577
Chest. 2003 Aug;124(2):740-3
pubmed: 12907568
Curr Opin Lipidol. 2017 Aug;28(4):291-299
pubmed: 28509674
JAMA. 2020 Apr 28;323(16):1574-1581
pubmed: 32250385
Infection. 2002 Jan;30(1):26-31
pubmed: 11876511
Crit Care Med. 2011 Feb;39(2):328-34
pubmed: 20975550
Heart Lung. 2020 Jul - Aug;49(4):348-349
pubmed: 32223988
Profiles Drug Subst Excip Relat Methodol. 2014;39:1-40
pubmed: 24794904
Clin Chim Acta. 2020 Jul;506:145-148
pubmed: 32178975
Fundam Appl Toxicol. 1997 Jan;35(1):78-83
pubmed: 9024675
Curr Med Res Opin. 2015 Nov;31(11):2105-17
pubmed: 26371518
Circulation. 2016 Apr 5;133(14):1426-8
pubmed: 26399660
JAMA Netw Open. 2019 Jan 4;2(1):e187223
pubmed: 30657536
JAMA Cardiol. 2020 Jul 1;5(7):811-818
pubmed: 32219356
Eur Heart J. 2014 Aug 21;35(32):2146-57
pubmed: 25053660
Eur Heart J. 2016 Aug 1;37(29):2315-2381
pubmed: 27222591
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Clin Pharmacokinet. 1992 Aug;23(2):106-31
pubmed: 1511528
Atherosclerosis. 2018 Aug;275:265-272
pubmed: 29980054
Thorax. 2016 Jul;71(7):646-51
pubmed: 26941271
Lancet. 2017 Oct 28;390(10106):1962-1971
pubmed: 28859947
Emerg Microbes Infect. 2020 Dec;9(1):757-760
pubmed: 32228222
Am J Med. 2012 Nov;125(11):1111-23
pubmed: 22835463
Pediatr Int. 2012 Aug;54(4):528-31
pubmed: 22375604
Am J Cardiol. 2008 Apr 17;101(8A):20B-26B
pubmed: 18375237
Am J Prev Cardiol. 2020 Mar;1:100009
pubmed: 32835347
Lancet Diabetes Endocrinol. 2017 Apr;5(4):280-290
pubmed: 28215937
Atherosclerosis. 2016 Dec;255:128-139
pubmed: 27839699
Rev Peru Med Exp Salud Publica. 2011 Jun;28(2):264-72
pubmed: 21845306
Arch Med Sci. 2020 Apr 25;16(3):490-496
pubmed: 32399094
J Acquir Immune Defic Syndr. 2009 Oct 1;52(2):235-9
pubmed: 19648824
Nat Rev Drug Discov. 2010 Apr;9(4):325-38
pubmed: 20305665
Turk J Gastroenterol. 2016 Jan;27(1):55-61
pubmed: 26674982
Heart Vessels. 2017 May;32(5):618-627
pubmed: 28013371
Immunology. 2018 May;154(1):69-75
pubmed: 29392731
JAMA Intern Med. 2016 Aug 1;176(8):1155-66
pubmed: 27357102
Circulation. 2004 Jun 1;109(21 Suppl 1):II42-8
pubmed: 15173062
J Clin Invest. 1985 Oct;76(4):1626-31
pubmed: 2997286
J Thromb Haemost. 2020 Jun;18(6):1469-1472
pubmed: 32302435
Arch Med Sci. 2018 Jan;14(1):1-21
pubmed: 29379528
Ann Intern Med. 2014 Mar 18;160(6):398-406
pubmed: 24723079
N Engl J Med. 2018 Oct 18;379(16):1540-1550
pubmed: 30146932
J Cardiovasc Pharmacol Ther. 2019 Jul;24(4):315-322
pubmed: 30909733
PLoS One. 2009 Nov 30;4(11):e8087
pubmed: 19956645
BMJ. 2009 Jun 16;338:b2137
pubmed: 19531550
Pharmacotherapy. 2007 Mar;27(3):325-32
pubmed: 17316144
Clin Nutr. 2018 Jun;37(3):948-957
pubmed: 28427779
JAMA Intern Med. 2013 Jul 22;173(14):1379-81
pubmed: 23753308
Pharmacotherapy. 2016 Jan;36(1):49-56
pubmed: 26799348
Am J Cardiol. 2007 Mar 19;99(6A):44C-46C
pubmed: 17368278
Annu Rev Med. 2018 Jan 29;69:133-145
pubmed: 29095667
Am J Clin Nutr. 1997 May;65(5 Suppl):1645S-1654S
pubmed: 9129504
Am J Hypertens. 2014 Jul;27(7):885-96
pubmed: 24610882
JAMA. 1982 Jun 11;247(22):3082
pubmed: 7077799
Expert Opin Investig Drugs. 2017 Feb;26(2):137-139
pubmed: 27967260
Pharmacol Res. 2020 Aug;158:104891
pubmed: 32389859
Platelets. 2020 May 18;31(4):490-496
pubmed: 32297540
Rom J Intern Med. 2007;45(2):165-70
pubmed: 18333370
J Am Coll Cardiol. 2020 May 12;75(18):2352-2371
pubmed: 32201335
N Engl J Med. 2015 Jun 18;372(25):2387-97
pubmed: 26039521
Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1084-H1090
pubmed: 32228252
Expert Rev Clin Pharmacol. 2018 Nov;11(11):1099-1112
pubmed: 30328735
Clin Med (Lond). 2017 Oct;17(5):403-407
pubmed: 28974587
Antiviral Res. 2013 Sep;99(3):417-35
pubmed: 23831494
PLoS One. 2014 Feb 05;9(2):e88103
pubmed: 24505395
J Am Coll Cardiol. 2011 Nov 8;58(20):2047-67
pubmed: 22051327
Crit Care Med. 2011 Aug;39(8):1871-8
pubmed: 21516038
Nephron. 2002;92(3):536-41
pubmed: 12372935
N Engl J Med. 2017 May 4;376(18):1713-1722
pubmed: 28304224
J Cell Physiol. 2017 Sep;232(9):2330-2338
pubmed: 28063230
Circulation. 2004 Jun 1;109(21 Suppl 1):II18-26
pubmed: 15173059
Metabolism. 1985 Jan;34(1):74-82
pubmed: 3855325
Ann Rheum Dis. 2015 Jan;74(1):89-95
pubmed: 24081439
Cardiovasc Res. 2018 Feb 1;114(2):226-232
pubmed: 29206916
BMJ. 2020 May 22;369:m1966
pubmed: 32444366
Ann Pharmacother. 1998 Jul-Aug;32(7-8):765-8
pubmed: 9681093
mBio. 2015 Aug 11;6(4):e01120
pubmed: 26265720
Lancet. 2020 May 22;:
pubmed: 32450107
Atherosclerosis. 2019 Sep;288:146-155
pubmed: 31404822
Curr Opin Cardiol. 2013 Jul;28(4):464-74
pubmed: 23736820
Am J Cardiol. 2007 Mar 19;99(6A):3C-18C
pubmed: 17368275
J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2889-934
pubmed: 24239923
Clin Pharmacokinet. 2018 Jul;57(7):769-779
pubmed: 29353350
Expert Opin Drug Metab Toxicol. 2015;11(9):1435-47
pubmed: 26058399
Cochrane Database Syst Rev. 2019 Jul 23;7:CD004477
pubmed: 31334568
N Engl J Med. 2017 Apr 20;376(16):1527-1539
pubmed: 28304242
Circulation. 2017 Jul 18;136(3):332-335
pubmed: 28716835
Eur Heart J. 2015 Nov 14;36(43):2975-83
pubmed: 26242714
Clin Cardiol. 2009 Jul;32(7):365-72
pubmed: 19609891
Biochem Pharmacol. 2015 Feb 1;93(3):343-51
pubmed: 25482567
Drugs. 2019 Aug;79(12):1349-1354
pubmed: 31301033
Antimicrob Agents Chemother. 2007 Aug;51(8):2965-8
pubmed: 17562808
Eur J Heart Fail. 2020 Jun;22(6):967-974
pubmed: 32485082
J Intern Med. 2020 Jun;287(6):746-747
pubmed: 32242993
J Gen Virol. 2015 Jan;96(Pt 1):46-51
pubmed: 25274854
Biomed Chromatogr. 2011 Jan;25(1-2):218-37
pubmed: 21204112
BMJ. 2020 Mar 25;368:m1182
pubmed: 32213507
Curr Opin Lipidol. 1997 Jun;8(3):131-7
pubmed: 9211060
Lancet. 2006 Feb 4;367(9508):413-8
pubmed: 16458766
Nutr Neurosci. 2017 Jun;20(5):291-296
pubmed: 26708730
J Geriatr Cardiol. 2013 Jun;10(2):151-8
pubmed: 23888175
Clin Gastroenterol Hepatol. 2020 Jun;18(7):1561-1566
pubmed: 32283325
N Engl J Med. 2020 Jun 18;382(25):2431-2440
pubmed: 32356627
Nat Commun. 2020 Mar 27;11(1):1620
pubmed: 32221306
Br J Clin Pharmacol. 2009 Sep;68(3):427-34
pubmed: 19740401
JAMA. 2020 May 12;323(18):1769-1770
pubmed: 32208485
Am J Med. 2017 Oct;130(10):1148-1150
pubmed: 28601545
N Engl J Med. 2019 Jan 3;380(1):11-22
pubmed: 30415628
Expert Opin Drug Saf. 2011 May;10(3):363-71
pubmed: 21417957
Biomed Res Int. 2017;2017:3204504
pubmed: 28630863
Pharmacol Ther. 1994 Aug;63(2):163-76
pubmed: 7809177
J Clin Transl Hepatol. 2020 Mar 28;8(1):18-24
pubmed: 32274342
Lipids Health Dis. 2015 Jun 06;14:53
pubmed: 26048287
Nutrition. 2018 Nov;55-56:7-14
pubmed: 29960160
Ann Intern Med. 2013 Jun 18;158(12):869-76
pubmed: 23778904
Antiviral Res. 2013 Jun;98(3):373-9
pubmed: 23603497
Expert Opin Drug Saf. 2012 Jan;11(1):151-9
pubmed: 22133050
Cardiovasc Diabetol. 2013 Jul 09;12:100
pubmed: 23835245
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Vasc Health Risk Manag. 2012;8:415-27
pubmed: 22910633
N Engl J Med. 2019 Aug 8;381(6):531-542
pubmed: 31390500
Am J Cardiovasc Drugs. 2002;2(2):91-106
pubmed: 14727985
Prostaglandins Leukot Essent Fatty Acids. 2016 May;108:45-50
pubmed: 27154364
J Clin Lipidol. 2020 Nov - Dec;14(6):807-817
pubmed: 33023859
PLoS One. 2019 Aug 1;14(8):e0220178
pubmed: 31369575
Lancet. 2013 Jan 5;381(9860):40-6
pubmed: 23122768
Curr Opin Lipidol. 2018 Aug;29(4):318-326
pubmed: 29746303
Int J Cardiol. 2015 Dec 15;201:247-52
pubmed: 26301648
Lancet. 2003 Feb 8;361(9356):477-85
pubmed: 12583947
Ther Clin Risk Manag. 2019 Jul 23;15:921-936
pubmed: 31413581
Cochrane Database Syst Rev. 2017 Jun 14;6:CD009744
pubmed: 28616955
JAMA. 1990 Jul 4;264(1):71-5
pubmed: 2355431
Epidemiology. 2001 Sep;12(5):565-9
pubmed: 11505177
Arch Intern Med. 2012 May 14;172(9):686-94
pubmed: 22493407
Expert Opin Drug Saf. 2018 Jan;17(1):25-37
pubmed: 29058944
N Engl J Med. 2020 Apr 23;382(17):1653-1659
pubmed: 32227760