Organ-specific ECM arrays for investigating cell-ECM interactions during stem cell differentiation.
ECM array
human pluripotent stem cell
organ decellulariation
organ derived extracellular matrix
pancreatic differentiation
Journal
Biofabrication
ISSN: 1758-5090
Titre abrégé: Biofabrication
Pays: England
ID NLM: 101521964
Informations de publication
Date de publication:
10 11 2020
10 11 2020
Historique:
received:
07
07
2020
accepted:
12
10
2020
pubmed:
13
10
2020
medline:
19
3
2022
entrez:
12
10
2020
Statut:
epublish
Résumé
Pluripotent stem cells are promising source of cells for tissue engineering, regenerative medicine and drug discovery applications. The process of stem cell differentiation is regulated by multi-parametric cues from the surrounding microenvironment, one of the critical one being cell interaction with extracellular matrix (ECM). The ECM is a complex tissue-specific structure which is an important physiological regulator of stem cell function and fate. Recapitulating this native ECM microenvironment niche is best facilitated by decellularized tissue/organ derived ECM, which can faithfully reproduce the physiological environment with high fidelity to
Identifiants
pubmed: 33045682
doi: 10.1088/1758-5090/abc05f
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020 IOP Publishing Ltd.