Comparison of Proteomic Responses as Global Approach to Antibiotic Mechanism of Action Elucidation.

Anti-Bacterial Agents / pharmacology Bacillus subtilis Bacterial Proteins / genetics Proteomics Tetracyclines

antibiotic chemical biology mechanism of action physiology proteomics

Journal

Antimicrobial agents and chemotherapy

ISSN: 1098-6596

Titre abrégé: Antimicrob Agents Chemother

Pays: United States

ID NLM: 0315061

Informations de publication

Date de publication:
16 12 2020

Historique:

received: 30 06 2020

accepted: 25 09 2020

pubmed: 14 10 2020

medline: 22 6 2021

entrez: 13 10 2020

Statut: epublish

Résumé

New antibiotics are urgently needed to address the mounting resistance challenge. In early drug discovery, one of the bottlenecks is the elucidation of targets and mechanisms. To accelerate antibiotic research, we provide a proteomic approach for the rapid classification of compounds into those with precedented and unprecedented modes of action. We established a proteomic response library of

Identifiants

DOI: 10.1128/AAC.01373-20 PMID: 33046497 PMC: PMC7927858

pubmed: 33046497

pii: AAC.01373-20

doi: 10.1128/AAC.01373-20

pmc: PMC7927858

pii:

doi:

Substances chimiques

Anti-Bacterial Agents 0

Bacterial Proteins 0

Tetracyclines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : NIGMS NIH HHS

ID : R01 GM121650

Pays : United States

Informations de copyright

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