Analysis of SARS-CoV-2 vertical transmission during pregnancy.
Adolescent
Adult
Antibodies, Viral
/ analysis
Betacoronavirus
/ genetics
COVID-19
Coronavirus Infections
/ diagnosis
Female
Genome, Viral
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Inflammation
Middle Aged
Pandemics
Pneumonia, Viral
/ diagnosis
Pregnancy
Pregnancy Complications, Infectious
/ diagnosis
SARS-CoV-2
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 10 2020
12 10 2020
Historique:
received:
19
07
2020
accepted:
18
09
2020
entrez:
13
10
2020
pubmed:
14
10
2020
medline:
27
10
2020
Statut:
epublish
Résumé
The impact of SARS-CoV-2 infection during gestation remains unclear. Here, we analyse the viral genome on maternal and newborns nasopharyngeal swabs, vaginal swabs, maternal and umbilical cord plasma, placenta and umbilical cord biopsies, amniotic fluids and milk from 31 mothers with SARS-CoV-2 infection. In addition, we also test specific anti-SARS-CoV-2 antibodies and expression of genes involved in inflammatory responses in placentas, and in maternal and umbilical cord plasma. We detect SARS-CoV-2 genome in one umbilical cord blood and in two at-term placentas, in one vaginal mucosa and in one milk specimen. Furthermore, we report the presence of specific anti-SARS-CoV-2 IgM and IgG antibodies in one umbilical cord blood and in one milk specimen. Finally, in the three documented cases of vertical transmission, SARS-CoV-2 infection was accompanied by a strong inflammatory response. Together, these data support the hypothesis that in utero SARS-CoV-2 vertical transmission, while low, is possible. These results might help defining proper obstetric management of COVID-19 pregnant women, or putative indications for mode and timing of delivery.
Identifiants
pubmed: 33046695
doi: 10.1038/s41467-020-18933-4
pii: 10.1038/s41467-020-18933-4
pmc: PMC7552412
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5128Références
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