IntraOmmaya compartmental radioimmunotherapy using
131I-omburtamab
Cerebrospinal fluid
Neuroblastoma
Pharmacokinetics
Radioimmunotherapy
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
13
08
2020
accepted:
20
09
2020
pubmed:
14
10
2020
medline:
29
5
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
Radioimmunotherapy (RIT) delivered through the cerebrospinal fluid (CSF) has been shown to be a safe and promising treatment for leptomeningeal metastases. Pharmacokinetic models for intraOmmaya antiGD2 monoclonal antibody Serial CSF samples were collected and radioassayed from 61 patients undergoing a total of 177 intraOmmaya administrations of The model fit CSF radioactivity data well (mean R = 96.4%). The median immunoreactivity of The 2-compartmental pharmacokinetic model when applied to intraOmmaya ClinicalTrials.gov , NCT00089245.
Identifiants
pubmed: 33047248
doi: 10.1007/s00259-020-05050-z
pii: 10.1007/s00259-020-05050-z
pmc: PMC8279045
mid: NIHMS1720534
doi:
Substances chimiques
Antibodies, Monoclonal, Murine-Derived
0
Iodine Radioisotopes
0
Iodine-131
0
Banques de données
ClinicalTrials.gov
['NCT00089245']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1166-1177Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
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