Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity.
heme oxygenase
metabolism
mitochondria
type II diabetes
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
08
07
2020
revised:
23
09
2020
accepted:
24
09
2020
pubmed:
14
10
2020
medline:
22
6
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
Milk thistle cold press oil (MTO) is an herbal remedy derived from Silybum marianum which contains a low level of silymarin and mixture of polyphenols and flavonoids. The effect of MTO on the cardiovascular and metabolic complications of obesity was studied in mice that were fed a high-fat diet (HFD) for 20 weeks and treated with MTO for the final 8 weeks of the diet. MTO treatment attenuated HFD-induced obesity, fasting hyperglycemia, hypertension, and induced markers of mitochondrial fusion and browning of white adipose. Markers of inflammation were also attenuated in both adipose and the liver of MTO-treated mice. In addition, MTO resulted in the improvement of liver fibrosis. These results demonstrate that MTO has beneficial actions to attenuate dietary obesity-induced weight gain, hyperglycemia, hypertension, inflammation, and suggest that MTO supplementation may prove beneficial to patients exhibiting symptoms of metabolic syndrome. PRACTICAL APPLICATIONS: Natural supplements are increasingly being considered as potential therapies for many chronic cardiovascular and metabolic diseases. Milk thistle cold press oil (MTO) is derived from Silybum marianum which is used as a dietary supplement in different parts of the world. The results of the present study demonstrate that MTO supplementation normalizes several metabolic and cardiovascular complications arising from dietary-induced obesity. MTO supplementation also had anti-inflammatory actions in the adipose as well as the liver. These results suggest that supplementation of MTO into the diet of obese individuals may afford protection against the worsening of cardiovascular and metabolic disease and improve inflammation and liver fibrosis.
Identifiants
pubmed: 33047319
doi: 10.1111/jfbc.13522
pmc: PMC7770619
mid: NIHMS1654084
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13522Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL051971
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM104357
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121334
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121748
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL139561
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Int J Biochem Cell Biol. 2013 Apr;45(4):783-91
pubmed: 23333619
Int J Mol Sci. 2019 Oct 12;20(20):
pubmed: 31614705
Int J Obes (Lond). 2012 Feb;36(2):244-53
pubmed: 21467998
Front Pharmacol. 2016 Sep 28;7:345
pubmed: 27733832
Hypertension. 1990 Aug;16(2):107-20
pubmed: 2166000
Front Cell Dev Biol. 2016 Aug 05;4:80
pubmed: 27547752
Diabetes. 2016 Sep;65(9):2502-15
pubmed: 27284105
J Biol Chem. 2002 Jan 18;277(3):1933-40
pubmed: 11707454
Horm Mol Biol Clin Investig. 2018 Sep 1;41(1):
pubmed: 30171810
Nature. 2015 Mar 12;519(7542):242-6
pubmed: 25533952
Oxid Med Cell Longev. 2013;2013:639541
pubmed: 24101950
Arch Biochem Biophys. 2019 Sep 30;673:108073
pubmed: 31425676
Nature. 2006 Dec 14;444(7121):860-7
pubmed: 17167474
Hypertension. 2008 Apr;51(4):884-90
pubmed: 18285617
Curr Pharm Des. 2013;19(15):2728-36
pubmed: 23092326
Circ Res. 2005 May 13;96(9):939-49
pubmed: 15890981
Nutrients. 2019 Aug 13;11(8):
pubmed: 31412639
J Nutr Biochem. 2020 Mar;77:108299
pubmed: 31841959
J Endocrinol. 2016 Jan;228(1):R19-29
pubmed: 26450134
Cell. 2006 Dec 15;127(6):1109-22
pubmed: 17112576
Am J Transl Res. 2016 Feb 15;8(2):1073-81
pubmed: 27158393
Endocrinology. 2013 Sep;154(9):3366-76
pubmed: 23825123
Endocrinology. 2009 Sep;150(9):4084-93
pubmed: 19470704
Int J Obes (Lond). 2014 Jan;38(1):132-9
pubmed: 23689359
Drug Metab Lett. 2008 Dec;2(4):290-300
pubmed: 19356108
Phytother Res. 2018 Oct;32(10):1933-1949
pubmed: 30015401
Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R561-7
pubmed: 22204957
J Sci Food Agric. 2012 May;92(7):1441-7
pubmed: 22102319
Antioxidants (Basel). 2020 Jan 01;9(1):
pubmed: 31906399
Mol Neurobiol. 2011 Oct;44(2):192-201
pubmed: 21499987
Curr Pharm Biotechnol. 2012 Jan;13(1):210-7
pubmed: 21466434
Redox Rep. 1999;4(1-2):35-41
pubmed: 10714274
J Nutr Biochem. 2016 May;31:150-65
pubmed: 27133434
Circ Res. 2003 Sep 19;93(6):507-14
pubmed: 12933701
Curr Med Chem. 2018;25(13):1577-1595
pubmed: 28618991
Hepatology. 2007 Sep;46(3):723-9
pubmed: 17680648
PLoS One. 2016 Feb 25;11(2):e0149670
pubmed: 26914024
Biomed Pharmacother. 2018 Apr;100:191-197
pubmed: 29428667
Biochem J. 2003 May 1;371(Pt 3):877-85
pubmed: 12585963
Int J Hypertens. 2012;2012:628147
pubmed: 22577519
Pharmacol Rev. 2008 Mar;60(1):79-127
pubmed: 18323402
Int J Mol Sci. 2017 Dec 02;18(12):
pubmed: 29207484
Mol Metab. 2018 Jan;7:35-44
pubmed: 29198749
Prostaglandins Other Lipid Mediat. 2018 Jul;137:30-39
pubmed: 29787809
Front Physiol. 2019 Feb 05;10:37
pubmed: 30804796
Cell Metab. 2016 Mar 8;23(3):441-53
pubmed: 26853749
Int J Hepatol. 2018 Jul 2;2018:3484107
pubmed: 30057822
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1143-8
pubmed: 25564660
J Med Food. 2015 Mar;18(3):290-8
pubmed: 25133972
Nutrients. 2019 Nov 21;11(12):
pubmed: 31766503
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10853-8
pubmed: 19541642
Obesity (Silver Spring). 2019 Oct;27(10):1634-1643
pubmed: 31441604
Cancers (Basel). 2013 Jun 19;5(2):726-38
pubmed: 24216999
Hepatology. 2012 Jan;55(1):77-85
pubmed: 21953442
Hepatology. 1999 Aug;30(2):462-8
pubmed: 10421655
Exp Cell Res. 2019 Jul 15;380(2):180-187
pubmed: 31039348
Adipocyte. 2015 Aug 07;5(1):1-10
pubmed: 27144091