Intestinal SALSA/dmbt1 levels are decreased in prematurely born infants.
Calcium-Binding Proteins
/ metabolism
Complement C1q
/ metabolism
DNA-Binding Proteins
/ metabolism
Feces
Female
Homeostasis
/ physiology
Humans
Immunoglobulin A
/ metabolism
Infant, Newborn
Infant, Premature
/ metabolism
Inflammation
/ metabolism
Intestinal Mucosa
/ metabolism
Male
Tumor Suppressor Proteins
/ metabolism
C1q
IgA
complement
dmbt1
gp340
infant
intestine
premature
Journal
Scandinavian journal of immunology
ISSN: 1365-3083
Titre abrégé: Scand J Immunol
Pays: England
ID NLM: 0323767
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
25
04
2020
revised:
09
09
2020
accepted:
06
10
2020
pubmed:
14
10
2020
medline:
3
2
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
The first months of life represent a crucial time period for an infant. Alongside establishing the early microbiome, the mucosal immunological homeostasis is being developed. Both processes may be perturbed in prematurely born infants. The glycoprotein SALSA plays a role in mucosal inflammation and microbial clearance. It is one of the most abundant molecules on the intestinal mucosal surfaces in early life. SALSA binds to many types of microbes and host defence molecules like IgA, C1q and collectin molecules. We here describe the development in faecal SALSA levels during the first three months of life. During these 90 days, the median SALSA level in full-term babies decreased from 1100 μg/mL (range 49-17 000 μg/mL) to 450 μg/mL (range 33-1000 μg/mL). Lower levels of SALSA were observed in prematurely born infants in the same time period. Our novel observation thus indicates an impact of prematurity on an important component of the infant intestinal immune system. Changes in SALSA in early life may have an effect on the early establishment of the human microbiome.
Substances chimiques
Calcium-Binding Proteins
0
DMBT1 protein, human
0
DNA-Binding Proteins
0
Immunoglobulin A
0
Tumor Suppressor Proteins
0
Complement C1q
80295-33-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12987Subventions
Organisme : Helsingin ja Uudenmaan Sairaanhoitopiiri
ID : TYH2018313
Organisme : Helsingin ja Uudenmaan Sairaanhoitopiiri
ID : TYH2019311
Organisme : Academy of Finland
ID : 292393
Organisme : Sigrid Juséliuksen Säätiö
Organisme : Pediatic Research Foundation
Informations de copyright
© 2020 The Scandinavian Foundation for Immunology.
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