Croconaine-Based Polymer Particles as Contrast Agents for Photoacoustic Imaging.
contrast agents
croconaine dyes
near-infrared absorbers
photoacoustic imaging
polymer nanoparticles
Journal
Macromolecular rapid communications
ISSN: 1521-3927
Titre abrégé: Macromol Rapid Commun
Pays: Germany
ID NLM: 9888239
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
03
08
2020
revised:
28
09
2020
pubmed:
14
10
2020
medline:
22
6
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
In the development and optimization of imaging methods, photoacoustic imaging (PAI) has become a powerful tool for preclinical biomedical diagnosis and detection of cancer. PAI probes can improve contrast and help identify pathogenic tissue. Such contrast agents must meet several requirements: they need to be biocompatible, and absorb strongly in the near-infrared (NIR) range, while relaxing the photoexcited state thermally and not radiatively. In this work, polymer nanoparticles are produced with croconaine as a monomer unit. Small molecular croconaine dyes are known to act as efficient pigments, which do not show photoluminescence. Here, for the first time croconaine copolymer nanoparticles are produced from croconic acid and a range of aromatic diamines. Following a dispersion polymerization protocol, this approach yields monodisperse particles of adjustable size. All synthesized polymers exhibit broad absorption within the NIR spectrum and therefore represent suitable candidates as contrast agents for PAI. The optical properties of these polymer particles are discussed with respect to the relation between particle size and outstanding photoacoustic performance. Biocompatibility of the polymer particles is demonstrated in cell viability experiments.
Identifiants
pubmed: 33047416
doi: 10.1002/marc.202000418
doi:
Substances chimiques
Contrast Media
0
Polymers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000418Subventions
Organisme : Deutsche Forschungsgemeinschaft
Organisme : Research Training Group "Tumor-Targeted Drug Delivery"
ID : 331065168
Organisme : Open access funding enabled and organized by Projekt DEAL
Informations de copyright
© The Authors. Published by Wiley-VCH GmbH.
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