(Hetero-)(arylidene)arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors.

Acetylcholinesterase / metabolism AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase / metabolism Drug Design Humans Hydrazines / chemistry Molecular Docking Simulation Monoamine Oxidase / metabolism Monoamine Oxidase Inhibitors / chemistry Neurodegenerative Diseases / drug therapy Neuroprotective Agents / chemistry Structure-Activity Relationship
(Hetero-)(arylidene)arylhydrazide AChE Docking analysis Kinetics MAOs Multitarget inhibitor

Journal

ACS combinatorial science
ISSN: 2156-8944
Titre abrégé: ACS Comb Sci
Pays: United States
ID NLM: 101540531

Informations de publication

Date de publication:
09 11 2020
Historique:
pubmed: 14 10 2020
medline: 10 9 2021
entrez: 13 10 2020
Statut: ppublish

Résumé

Fourteen (hetero-)(arylidene)arylhydrazide derivatives (

Identifiants

DOI: 10.1021/acscombsci.0c00136 PMID: 33047950
pubmed: 33047950
doi: 10.1021/acscombsci.0c00136
doi:

Substances chimiques

Hydrazines 0
Monoamine Oxidase Inhibitors 0
Neuroprotective Agents 0
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase EC 1.14.11.33
Monoamine Oxidase EC 1.4.3.4
monoamine oxidase A, human EC 1.4.3.4.
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

592-599

Auteurs

Ashique Palakkathondi (A)

Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna-679322, Kerala, India.

Jong Min Oh (JM)

Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.

Sanal Dev (S)

Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna-679322, Kerala, India.

T M Rangarajan (TM)

Department of Chemistry, Sri Venketeswara College, University of Delhi, New Delhi-110021, India.
ORCID: 0000-0002-5972-1879

Swafvan Kaipakasseri (S)

Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna-679322, Kerala, India.

Fathima Sahla Kavully (FS)

Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna-679322, Kerala, India.

Nicola Gambacorta (N)

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", Via E. Orabona, 4, I-70125 Bari, Italy.

Orazio Nicolotti (O)

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", Via E. Orabona, 4, I-70125 Bari, Italy.
ORCID: 0000-0001-6533-5539

Hoon Kim (H)

Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
ORCID: 0000-0002-7203-3712

Bijo Mathew (B)

Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad-678557, Kerala, India.
Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus, Kochi-682 041, India.
ORCID: 0000-0002-6658-4497

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Composés chimiques organiques › Hydrazines › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › (Hetero-)(arylidene)arylhydrazides as...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › (Hetero-)(arylidene)arylhydrazides as...