Cognitive evaluation in cerebral small vessel disease: towards an evidence-based identification of the reference standards. Part 1. A systematic review and qualitative data synthesis.
Attention and executive functions
Cerebral small vessel disease
Cognitive domains
Neuropsychological tools
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
17
08
2020
accepted:
07
10
2020
revised:
05
10
2020
pubmed:
14
10
2020
medline:
5
11
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
Cerebral small vessel disease (cSVD) is a leading cause of cognitive impairment in the elderly. Despite cSVD cognitive profile is thought to be mainly characterized by attention and executive functions deficits, there is no definite agreement on the standards for its evaluation. This systematic review aims at identifying cognitive domains and neuropsychological tools specifically chosen in the assessment of cognitive impairment related to cSVD, and the temporal and geographic trends in their utilization. Following PRISMA guidelines, original articles focused on cSVD patient samples neuropsychologically evaluated were searched using PubMed, Scopus and PsycINFO databases without language or time restrictions (PROSPERO registration number CRD42018089882; date 27-02-2018). We screened 13,688 studies and included 298 in the qualitative data synthesis. Global cognitive functioning and attention/executive functions were the most evaluated domains (87% and 69%, respectively). Mini Mental State Examination was the most used screening tool (73%), followed by MoCA (14%) whose utilization rapidly increased over the last years. The most frequently used second level tests were phonemic and semantic fluencies (39% and 30%, respectively), Trail Making Test (TMT) part A and B (31% and 32%, respectively), Stroop (31.5%), and Boston naming (30%). All tests resulted stably utilized over time, except for semantic fluency and Stroop whose use increased. Phonemic fluency and Boston naming were the most used in North America (51% and 45%, respectively), TMT in Europe (43%), and Stroop and semantic fluency in Asia (43% and 40%, respectively). This systematic review confirms that attention/executive functions domain is the most commonly evaluated in cSVD together with lexical retrieval abilities based on executive control processes. Temporal and geographic variability emerged in the choice of tests. CRD42018089882 (27-02-2018).
Sections du résumé
BACKGROUND
BACKGROUND
Cerebral small vessel disease (cSVD) is a leading cause of cognitive impairment in the elderly. Despite cSVD cognitive profile is thought to be mainly characterized by attention and executive functions deficits, there is no definite agreement on the standards for its evaluation. This systematic review aims at identifying cognitive domains and neuropsychological tools specifically chosen in the assessment of cognitive impairment related to cSVD, and the temporal and geographic trends in their utilization.
METHODS
METHODS
Following PRISMA guidelines, original articles focused on cSVD patient samples neuropsychologically evaluated were searched using PubMed, Scopus and PsycINFO databases without language or time restrictions (PROSPERO registration number CRD42018089882; date 27-02-2018).
RESULTS
RESULTS
We screened 13,688 studies and included 298 in the qualitative data synthesis. Global cognitive functioning and attention/executive functions were the most evaluated domains (87% and 69%, respectively). Mini Mental State Examination was the most used screening tool (73%), followed by MoCA (14%) whose utilization rapidly increased over the last years. The most frequently used second level tests were phonemic and semantic fluencies (39% and 30%, respectively), Trail Making Test (TMT) part A and B (31% and 32%, respectively), Stroop (31.5%), and Boston naming (30%). All tests resulted stably utilized over time, except for semantic fluency and Stroop whose use increased. Phonemic fluency and Boston naming were the most used in North America (51% and 45%, respectively), TMT in Europe (43%), and Stroop and semantic fluency in Asia (43% and 40%, respectively).
CONCLUSIONS
CONCLUSIONS
This systematic review confirms that attention/executive functions domain is the most commonly evaluated in cSVD together with lexical retrieval abilities based on executive control processes. Temporal and geographic variability emerged in the choice of tests.
PROSPERO REGISTRATION NUMBER
UNASSIGNED
CRD42018089882 (27-02-2018).
Identifiants
pubmed: 33048216
doi: 10.1007/s00415-020-10262-2
pii: 10.1007/s00415-020-10262-2
doi:
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4563-4572Informations de copyright
© 2020. Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Rensma SP, van Sloten TT, Launer LJ, Stehouwer CDA (2018) Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: a systematic review and meta-analysis. Neurosci Biobehav Rev. https://doi.org/10.1016/j.neubiorev.2018.04.003
doi: 10.1016/j.neubiorev.2018.04.003
pubmed: 29656031
pmcid: 6123527
O’Brien JT, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L et al (2003) Vascular cognitive impairment. Lancet Neurol 2:89–98
doi: 10.1016/S1474-4422(03)00305-3
Pantoni L (2010) Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9:689–701
doi: 10.1016/S1474-4422(10)70104-6
Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG (2009) Cadasil. Lancet Neurol 8:643–653
doi: 10.1016/S1474-4422(09)70127-9
Salvadori E, Pantoni L (2020) The role of the neuropsychologist in memory clinics. Neurol Sci. https://doi.org/10.1007/s10072-020-04253-4
doi: 10.1007/s10072-020-04253-4
pubmed: 31950460
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M et al (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. https://doi.org/10.1186/2046-4053-4-1
doi: 10.1186/2046-4053-4-1
pubmed: 26693720
pmcid: 4688988
Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R et al (2013) Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 12:822–838
doi: 10.1016/S1474-4422(13)70124-8
Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE et al (2006) National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 37:2220–2241
doi: 10.1161/01.STR.0000237236.88823.47