Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1.
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
27 10 2020
27 10 2020
Historique:
pubmed:
14
10
2020
medline:
10
4
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
The oxylipins, 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid (5S,12S-diHETE) and 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid (5S,15S-diHETE), have been identified in cell exudates and have chemotactic activity toward eosinophils and neutrophils. Their biosynthesis has been proposed to occur by sequential oxidations of arachidonic acid (AA) by lipoxygenase enzymes, specifically through oxidation of AA by h5-LOX followed by h12-LOX, h15-LOX-1, or h15-LOX-2. In this work, h15-LOX-1 demonstrates altered positional specificity when reacting with 5S-HETE, producing 90% 5S,12S-diHETE, instead of 5S,15S-diHETE, with kinetics 5-fold greater than that of h12-LOX. This is consistent with previous work in which h15-LOX-1 reacts with 7S-HDHA, producing the noncanonical, DHA-derived, specialized pro-resolving mediator, 7S,14S-diHDHA. It is also determined that oxygenation of 5S-HETE by h15-LOX-2 produces 5S,15S-diHETE and its biosynthetic
Identifiants
pubmed: 33048542
doi: 10.1021/acs.biochem.0c00622
pmc: PMC7721368
mid: NIHMS1650494
doi:
Substances chimiques
Arachidonic Acids
0
Hydroxyeicosatetraenoic Acids
0
Lipoxins
0
Arachidonic Acid
27YG812J1I
ALOX15 protein, human
EC 1.13.11.33
ALOX15B protein, human
EC 1.13.11.33
Arachidonate 15-Lipoxygenase
EC 1.13.11.33
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4118-4130Subventions
Organisme : NHGRI NIH HHS
ID : R01 HG011405
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL136784
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131835
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL136784
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM105671
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114405
Pays : United States
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