Impaired Transport Activity of Human Organic Anion Transporters (OATs) and Organic Anion Transporting Polypeptides (OATPs) by Wnt Inhibitors.

Biological Transport Humans Kidney / metabolism Organic Anion Transporters / metabolism Organic Anion Transporters, Sodium-Independent Peptides / metabolism
Molecular regulation Organic anion transporters Organic anion transporting polypeptides Wnt inhibitors

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
02 2021
Historique:
received: 07 08 2020
revised: 21 09 2020
accepted: 06 10 2020
pubmed: 14 10 2020
medline: 22 6 2021
entrez: 13 10 2020
Statut: ppublish

Résumé

The Wnt/β-catenin signaling pathway is dysregulated in diseases and Wnt inhibitors like PRI-724 are in clinical development. This study evaluated the regulatory actions of PRI-724 and other Wnt inhibitors on the transport activity of human renal Organic anion transporters (OATs) and Organic anion transporting polypeptides (OATPs). The substrate uptake by OAT4 and OATP2B1 was markedly decreased by PRI-724 (V

Identifiants

DOI: 10.1016/j.xphs.2020.10.009 PMID: 33049263
pubmed: 33049263
pii: S0022-3549(20)30597-9
doi: 10.1016/j.xphs.2020.10.009
pii:
doi:

Substances chimiques

Organic Anion Transporters 0
Organic Anion Transporters, Sodium-Independent 0
Peptides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

914-924

Informations de copyright

Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Auteurs

Youmna Ali (Y)

The University of Sydney, Sydney Pharmacy School, Faculty of Medicine and Health, New South Wales, 2006 Australia.

Tahiatul Shams (T)

The University of Sydney, Sydney Pharmacy School, Faculty of Medicine and Health, New South Wales, 2006 Australia.

Zhengqi Cheng (Z)

The University of Sydney, Sydney Pharmacy School, Faculty of Medicine and Health, New South Wales, 2006 Australia.

Yue Li (Y)

The University of Sydney, Sydney Pharmacy School, Faculty of Medicine and Health, New South Wales, 2006 Australia.

Chelsea Siu-Wai Chun (CS)

The University of Sydney, Sydney Pharmacy School, Faculty of Medicine and Health, New South Wales, 2006 Australia.

Wenying Shu (W)

The University of Sydney, Sydney Pharmacy School, Faculty of Medicine and Health, New South Wales, 2006 Australia; Department of Pharmacy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangdong Province, 511400 China.

Xiaofeng Bao (X)

School of Pharmacy, Nantong University, Nantong, Jiangsu Province, 226019 China.

Ling Zhu (L)

The University of Sydney, Save Sight Institute, Sydney, New South Wales, 2000 Australia.

Michael Murray (M)

The University of Sydney, Discipline of Pharmacology, Faculty of Medicine and Health, New South Wales 2006, Australia.

Fanfan Zhou (F)

The University of Sydney, Sydney Pharmacy School, Faculty of Medicine and Health, New South Wales, 2006 Australia. Electronic address: Fanfan.zhou@sydney.edu.au.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Transport biologique › Impaired Transport Activity of Human Organic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Impaired Transport Activity of Human Organic...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Impaired Transport Activity of Human Organic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Impaired Transport Activity of Human Organic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques sodium-indépendants › Impaired Transport Activity of Human Organic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Impaired Transport Activity of Human Organic...