HOX genes and the NF-κB pathway: A convergence of developmental biology, inflammation and cancer biology.
Cancer
HOX
Homeostasis
Inflammation
NF-KB
Journal
Biochimica et biophysica acta. Reviews on cancer
ISSN: 1879-2561
Titre abrégé: Biochim Biophys Acta Rev Cancer
Pays: Netherlands
ID NLM: 9806362
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
27
06
2020
revised:
11
09
2020
accepted:
07
10
2020
pubmed:
14
10
2020
medline:
20
1
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
The roles of HOX transcription factors as oncogenes and tumor suppressor genes, and the NF-KB pathway in chronic inflammation, both leading to cancer are well-established. HOX transcription factors are members of an evolutionarily conserved family of proteins required for anteroposterior body axis patterning during embryonic development, and are often dysregulated in cancer. The NF-KB pathway aids inflammation and immunity but it is also important during embryonic development. It is frequently activated in both solid and hematological malignancies. NF-KB and HOX proteins can influence each other through mutual transcriptional regulation, protein-protein interactions, and regulation of upstream and downstream interactors. These interactions have important implications both in homeostasis and in disease. In this review, we summarize the role of HOX proteins in regulating inflammation in homeostasis and disease- with a particular emphasis on cancer. We also describe the relationship between HOX genes and the NF-KB pathway, and discuss potential therapeutic strategies.
Identifiants
pubmed: 33049277
pii: S0304-419X(20)30169-4
doi: 10.1016/j.bbcan.2020.188450
pii:
doi:
Substances chimiques
Homeodomain Proteins
0
NF-kappa B
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
188450Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.