New polymorphisms at MTNR1A gene and their association with reproductive resumption in sarda breed sheep.
Dairy ewes
MTNR1A gene
Reproductive resumption
SNPs
Journal
Theriogenology
ISSN: 1879-3231
Titre abrégé: Theriogenology
Pays: United States
ID NLM: 0421510
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
17
07
2020
revised:
05
10
2020
accepted:
06
10
2020
pubmed:
14
10
2020
medline:
22
6
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
The aim of this study was to characterize the MTNR1A locus in Sarda sheep breed, in order to identify potential single nucleotide polymorphisms (SNPs) associated with reproductive resumption. The reproductive performance of 200 lactating ewes, aged 3-5 years, with body condition score (BCS) 2.5-4.0, at least at their third lambing were monitored for two consecutive years. In both year the enrolled ewes were exposed for 100 days to 10 adult, fertile rams. Mating, pregnancy and lambing for each ewe were recorded in order to evaluate differences in reproductive performance according to the analysed genotypes. From individual blood samples, DNA was extracted to amplify and to sequence promotor, the coding region, a part of intron and of 3' Untranslated region (3' UTR) of the MTNR1A gene. A total number of 29 SNPs were found (named SNP1 to SNP29), five of which caused also amino acid changes. The polymorphic sites found at positions g.17355452C > T (SNP16, rs430181568) and g.17355358C > T (SNP17, rs407388227) were linked (D' = 1 and r
Identifiants
pubmed: 33049568
pii: S0093-691X(20)30547-1
doi: 10.1016/j.theriogenology.2020.10.006
pii:
doi:
Substances chimiques
Receptor, Melatonin, MT1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
438-444Informations de copyright
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