Immunization with Plant-Derived Multimeric H5 Hemagglutinins Protect Chicken against Highly Pathogenic Avian Influenza Virus H5N1.
avian flu
chicken
crude extracts
immunization
oligomerization
plant-expressed hemagglutinin (H5)
protective immune response
vaccination
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
09 Oct 2020
09 Oct 2020
Historique:
received:
22
09
2020
revised:
02
10
2020
accepted:
05
10
2020
entrez:
14
10
2020
pubmed:
15
10
2020
medline:
15
10
2020
Statut:
epublish
Résumé
Since 2003, H5N1 highly pathogenic avian influenza viruses (HPAIV) have not only caused outbreaks in poultry but were also transmitted to humans with high mortality rates. Vaccination is an efficient and economical means of increasing immunity against infections to decrease the shedding of infectious agents in immunized animals and to reduce the probability of further infections. Subunit vaccines from plants are the focus of modern vaccine developments. In this study, plant-made hemagglutinin (H5) trimers were purified from transiently transformed
Identifiants
pubmed: 33050224
pii: vaccines8040593
doi: 10.3390/vaccines8040593
pmc: PMC7712794
pii:
doi:
Types de publication
Journal Article
Langues
eng
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