A Comparison of Cell Activation, Exhaustion, and Expression of HIV Coreceptors and Restriction Factors in HIV-1- and HIV-2-Infected Nonprogressors.
CD4 T cells
HIV
coreceptors
restriction factors
Journal
AIDS research and human retroviruses
ISSN: 1931-8405
Titre abrégé: AIDS Res Hum Retroviruses
Pays: United States
ID NLM: 8709376
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
15
10
2020
medline:
19
8
2021
entrez:
14
10
2020
Statut:
ppublish
Résumé
Human immunodeficiency viruses induce rare attenuated diseases due either to HIV-1 in the exceptional long-term nonprogressors (LTNPs) or to HIV-2 in West Africa. To better understand characteristics of these two disease types we performed a multiplex comparative analysis of cell activation, exhaustion, and expression of coreceptors and restriction factors in CD4 T cells susceptible to harbor those viruses. We analyzed by flow cytometry the expression of HLA-DR, PD1, CCR5, CXCR6, SAMHD1, Blimp-1, and TRIM5α on CD4 T cell subsets from 10 HIV-1
Identifiants
pubmed: 33050708
doi: 10.1089/AID.2020.0084
doi:
Substances chimiques
Antiviral Restriction Factors
0
Tripartite Motif Proteins
0
TRIM5 protein, human
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
214-223Investigateurs
Victor Appay
(V)
Brigitte Autran
(B)
Françoise Brun-Vezinet
(F)
Nathalie Chaghil
(N)
Diane Descamps
(D)
Anne Hosmalin
(A)
Gianfranco Pancino
(G)
Nicolas Manel
(N)
Lucie Marchand
(L)
Livia Pedroza-Martins
(L)
Asier Sàez-Cirion
(A)
Vincent Vieillard
(V)
Henri Agut
(H)
Jean-Pierre Clauvel
(JP)
Dominique Costagliola
(D)
Patrice Debré
(P)
Ioannis Theodorou
(I)
Didier Sicard
(D)
Jean-Paul Viard
(JP)
Francis Barin
(F)
Vincent Vieillard
(V)
Brigitte Autran
(B)