Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection.


Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
11 Oct 2020
Historique:
entrez: 14 10 2020
pubmed: 15 10 2020
medline: 15 10 2020
Statut: epublish

Résumé

Cross-reactive immune responses elicited by seasonal coronaviruses might impact SARS-CoV-2 susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in pre-pandemic sera from patients with prior PCR-confirmed seasonal coronavirus infection. While neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

Identifiants

pubmed: 33052353
doi: 10.1101/2020.10.08.20209650
pmc: PMC7553167
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI078788
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007739
Pays : United States

Commentaires et corrections

Type : UpdateIn

Références

Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
J Exp Med. 2020 Nov 2;217(11):
pubmed: 32692348
J Clin Microbiol. 2010 Aug;48(8):2940-7
pubmed: 20554810
Science. 2020 Aug 7;369(6504):731-736
pubmed: 32540900
Nat Med. 2020 Nov;26(11):1691-1693
pubmed: 32929268
Science. 2020 Nov 27;370(6520):
pubmed: 32994364
Nature. 2020 Nov;587(7833):270-274
pubmed: 32726801
Trends Microbiol. 2016 Jun;24(6):490-502
pubmed: 27012512
Am J Med. 2015 Nov;128(11):1251.e11-20
pubmed: 26087047
J Clin Virol. 2012 Feb;53(2):135-9
pubmed: 22188723

Auteurs

Daniel Poston (D)

Laboratory of Retrovirology, The Rockefeller University, 1230 York Avenue, New York NY 10065.
Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, 1300 York Avenue, New York NY 10021.

Yiska Weisblum (Y)

Laboratory of Retrovirology, The Rockefeller University, 1230 York Avenue, New York NY 10065.

Helen Wise (H)

Royal Infirmary of Edinburgh, NHS Lothian, 51 Little France Crescent, Edinburgh EH16 4SA.

Kate Templeton (K)

Royal Infirmary of Edinburgh, NHS Lothian, 51 Little France Crescent, Edinburgh EH16 4SA.

Sara Jenks (S)

Royal Infirmary of Edinburgh, NHS Lothian, 51 Little France Crescent, Edinburgh EH16 4SA.

Theodora Hatziioannou (T)

Laboratory of Retrovirology, The Rockefeller University, 1230 York Avenue, New York NY 10065.

Paul Bieniasz (P)

Laboratory of Retrovirology, The Rockefeller University, 1230 York Avenue, New York NY 10065.
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York NY 10065.

Classifications MeSH