On the propagation of the OH radical produced by Cu-amyloid beta peptide model complexes. Insight from molecular modelling.

Amino Acids / chemistry Amyloid beta-Peptides / chemistry Copper Homeostasis Hydroxyl Radical / metabolism Models, Molecular Molecular Dynamics Simulation Oxidation-Reduction Oxidative Stress

Journal

Metallomics : integrated biometal science
ISSN: 1756-591X
Titre abrégé: Metallomics
Pays: England
ID NLM: 101478346

Informations de publication

Date de publication:
01 11 2020
Historique:
pubmed: 15 10 2020
medline: 6 10 2021
entrez: 14 10 2020
Statut: ppublish

Résumé

Oxidative stress and metal dyshomeostasis are considered as crucial factors in the pathogenesis of Alzheimer's disease (AD). Indeed, transition metal ions such as Cu(ii) can generate Reactive Oxygen Species (ROS) via O

Identifiants

DOI: 10.1039/d0mt00113a PMID: 33052996
pubmed: 33052996
doi: 10.1039/d0mt00113a
doi:

Substances chimiques

Amino Acids 0
Amyloid beta-Peptides 0
Hydroxyl Radical 3352-57-6
Copper 789U1901C5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1765-1780

Auteurs

Federica Arrigoni (F)

Department of Biotechnologies and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. luca.bertini@unimib.it.

Fabio Rizza (F)

Renata Tisi (R)

Luca De Gioia (L)

Giuseppe Zampella (G)

Luca Bertini (L)

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › On the propagation of the OH radical produced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › On the propagation of the OH radical produced...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › On the propagation of the OH radical produced...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › On the propagation of the OH radical produced...
questionsmedicales.fr › Produits chimiques inorganiques › Radical hydroxyle › On the propagation of the OH radical produced...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › On the propagation of the OH radical produced...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › On the propagation of the OH radical produced...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › On the propagation of the OH radical produced...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › On the propagation of the OH radical produced...