The Influence of Gestational Diabetes Mellitus upon the Selected Parameters of the Maternal and Fetal System of Insulin-Like Growth Factors (IGF-1, IGF-2, IGFBP1-3)-A Review and a Clinical Study.
gestational diabetes mellitus
insulin like-binding proteins
insulin-like growth factor I
insulin-like growth factor II
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
12 Oct 2020
12 Oct 2020
Historique:
received:
04
09
2020
revised:
03
10
2020
accepted:
06
10
2020
entrez:
15
10
2020
pubmed:
16
10
2020
medline:
16
10
2020
Statut:
epublish
Résumé
Gestational diabetes mellitus (GDM), defined as impaired glucose tolerance with onset or first recognition in pregnancy, increases the risk of not only maternal but also fetal and neonatal complications. Given the structural similarity of insulin-like growth factors with insulin and participation of components of the insulin-like growth factor system in glucose homeostasis, we hypothesized that the IGF axis is involved in the development of GDM complications or its pathogenesis. The aim of this study was to evaluate the effect of GDM on the selected parameters of the insulin-like growth factors (IGF-1, IGF-2, IGFBP1-3) in the maternal and fetal blood. The clinical material of this case-control study included 109 pregnant women and their offspring. The study group ( The analysis of concentrations of IGF-1, -2 and IGFBP-3 in peripheral blood as well as umbilical cord blood did not demonstrate a statistically significant difference between the study group and the control group. Significantly lower concentration of IGFBP-1, IGFBP-2 in peripheral blood and in umbilical cord blood was detected in the study group in comparison to the control group. A statistically positive correlation between the concentration of IGF-1 in umbilical cord serum of newborn babies born to women with gestational diabetes and the length of a baby after its birth was observed. Gestational diabetes mellitus does not significantly affect the concentrations of IGF-1, -2, IGFBP-3 in the peripheral blood and umbilical cord blood, but has the greatest influence on maternal and fetal IGFBP-2 concentrations. A positive correlation between the concentration of IGF-1 in umbilical cord blood and the length of a newborn suggests an influence of IGF-1 on the process of fetal development.
Sections du résumé
BACKGROUND
BACKGROUND
Gestational diabetes mellitus (GDM), defined as impaired glucose tolerance with onset or first recognition in pregnancy, increases the risk of not only maternal but also fetal and neonatal complications. Given the structural similarity of insulin-like growth factors with insulin and participation of components of the insulin-like growth factor system in glucose homeostasis, we hypothesized that the IGF axis is involved in the development of GDM complications or its pathogenesis. The aim of this study was to evaluate the effect of GDM on the selected parameters of the insulin-like growth factors (IGF-1, IGF-2, IGFBP1-3) in the maternal and fetal blood.
METHODS
METHODS
The clinical material of this case-control study included 109 pregnant women and their offspring. The study group (
RESULTS
RESULTS
The analysis of concentrations of IGF-1, -2 and IGFBP-3 in peripheral blood as well as umbilical cord blood did not demonstrate a statistically significant difference between the study group and the control group. Significantly lower concentration of IGFBP-1, IGFBP-2 in peripheral blood and in umbilical cord blood was detected in the study group in comparison to the control group. A statistically positive correlation between the concentration of IGF-1 in umbilical cord serum of newborn babies born to women with gestational diabetes and the length of a baby after its birth was observed.
CONCLUSIONS
CONCLUSIONS
Gestational diabetes mellitus does not significantly affect the concentrations of IGF-1, -2, IGFBP-3 in the peripheral blood and umbilical cord blood, but has the greatest influence on maternal and fetal IGFBP-2 concentrations. A positive correlation between the concentration of IGF-1 in umbilical cord blood and the length of a newborn suggests an influence of IGF-1 on the process of fetal development.
Identifiants
pubmed: 33053704
pii: jcm9103256
doi: 10.3390/jcm9103256
pmc: PMC7600633
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Pediatrics. 2002 Jun;109(6):1131-5
pubmed: 12042554
Early Hum Dev. 2016 Feb;93:39-42
pubmed: 26765797
J Clin Endocrinol Metab. 2002 Jun;87(6):2978-83
pubmed: 12050283
Obstet Gynecol. 2001 May;97(5 Pt 1):734-41
pubmed: 11339926
Endocrinology. 2018 Feb 1;159(2):570-578
pubmed: 29165552
Diabetes. 2012 Sep;61(9):2248-54
pubmed: 22554827
Endocr Rev. 2002 Dec;23(6):824-54
pubmed: 12466191
J Nutr. 2003 May;133(5 Suppl 2):1741S-1746S
pubmed: 12730493
Semin Perinatol. 2000 Apr;24(2):120-35
pubmed: 10805168
Am J Perinatol. 2016 Nov;33(13):1273-1281
pubmed: 27490771
J Clin Invest. 1989 May;83(5):1717-23
pubmed: 2651479
World J Diabetes. 2017 Dec 15;8(12):489-511
pubmed: 29290922
J Clin Endocrinol Metab. 2003 Apr;88(4):1687-91
pubmed: 12679458
Semin Fetal Neonatal Med. 2013 Jun;18(3):118-123
pubmed: 23639574
J Clin Endocrinol Metab. 2012 May;97(5):1720-8
pubmed: 22419731
Epigenetics. 2012 Oct;7(10):1125-32
pubmed: 22907587
BMC Pregnancy Childbirth. 2010 Feb 09;10:7
pubmed: 20144210
Front Endocrinol (Lausanne). 2019 Jul 12;10:444
pubmed: 31354622
Ceylon Med J. 2007 Jun;52(2):48-52
pubmed: 17691559
Clin Endocrinol (Oxf). 2007 Mar;66(3):322-8
pubmed: 17302863
Diabetes. 2016 Nov;65(11):3495-3504
pubmed: 27468747
J Clin Invest. 1993 Oct;92(4):1903-9
pubmed: 8408642
BMJ Open Diabetes Res Care. 2020 Feb;8(1):
pubmed: 32049636
Endocr J. 1996 Apr;43(2):221-31
pubmed: 9026269
J Perinatol. 2015 Jan;35(1):32-8
pubmed: 25078866
Diabetes Care. 2005 Jan;28(1):120-5
pubmed: 15616244
Trends Endocrinol Metab. 2009 May;20(4):153-62
pubmed: 19349193
Diabetes Care. 2002 Sep;25(9):1539-44
pubmed: 12196424