Long non-coding RNAs in liver diseases: Focusing on nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease.
Etiology
Liver diseases
RNA, Long noncoding
Journal
Clinical and molecular hepatology
ISSN: 2287-285X
Titre abrégé: Clin Mol Hepatol
Pays: Korea (South)
ID NLM: 101586730
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
07
2020
accepted:
31
08
2020
entrez:
15
10
2020
pubmed:
16
10
2020
medline:
18
9
2021
Statut:
ppublish
Résumé
Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.
Identifiants
pubmed: 33053941
pii: cmh.2020.0166
doi: 10.3350/cmh.2020.0166
pmc: PMC7641564
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
705-714Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002529
Pays : United States
Organisme : NIAAA NIH HHS
ID : UH2 AA026903
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA025208
Pays : United States
Organisme : CSRD VA
ID : I01 CX000361
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107682
Pays : United States
Organisme : NIAAA NIH HHS
ID : UH3 AA026903
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA026917
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA026385
Pays : United States
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