Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
26
11
2019
accepted:
14
08
2020
entrez:
15
10
2020
pubmed:
16
10
2020
medline:
14
4
2022
Statut:
epublish
Résumé
As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-β1 levels and the proportion of regulatory T cells. The plasma IL-10:IL-17A ratio increased among intervention children during the trial. Our findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies.
Identifiants
pubmed: 33055153
pii: 6/42/eaba2578
doi: 10.1126/sciadv.aba2578
pmc: PMC7556828
pii:
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Références
Nat Rev Immunol. 2008 Jul;8(7):523-32
pubmed: 18566595
Nature. 2017 Nov 23;551(7681):457-463
pubmed: 29088705
Environ Int. 2019 Sep;130:104894
pubmed: 31220749
PeerJ. 2018 Mar 19;6:e4508
pubmed: 29576975
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
pubmed: 18936492
Front Immunol. 2019 Jan 22;10:19
pubmed: 30723474
N Engl J Med. 2016 Aug 4;375(5):411-421
pubmed: 27518660
Front Microbiol. 2019 Mar 22;10:536
pubmed: 30967847
Environ Int. 2019 Nov;132:105069
pubmed: 31400602
Clin Exp Allergy. 2015 Sep;45(9):1419-29
pubmed: 25944283
Front Pediatr. 2017 Jul 31;5:165
pubmed: 28824889
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8334-9
pubmed: 22566627
Nat Commun. 2013;4:1431
pubmed: 23385576
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
PLoS One. 2017 Nov 16;12(11):e0187852
pubmed: 29145477
Appl Environ Microbiol. 2009 Dec;75(23):7537-41
pubmed: 19801464
Future Microbiol. 2018 Jun 1;13:737-744
pubmed: 29771153
Nat Immunol. 2010 May;11(5):373-84
pubmed: 20404851
Adv Exp Med Biol. 2008;635:113-34
pubmed: 18841708
Allergy. 2019 Aug;74(8):1445-1456
pubmed: 30835837
Cell. 2018 Sep 6;174(6):1406-1423.e16
pubmed: 30193113
Sci Total Environ. 2018 Jun 15;627:1018-1038
pubmed: 29426121
Expert Rev Anti Infect Ther. 2010 Jan;8(1):33-50
pubmed: 20014900
Int J Environ Res Public Health. 2019 Aug 16;16(16):
pubmed: 31426345
Nat Commun. 2018 Jan 10;9(1):141
pubmed: 29321519
Chest. 2000 Apr;117(4):1162-72
pubmed: 10767254
Br J Pharmacol. 2018 Dec;175(24):4415-4429
pubmed: 29782640
Microbiologyopen. 2019 Mar;8(3):e00645
pubmed: 29808965
Sci Rep. 2017 Mar 31;7:45651
pubmed: 28361981
Allergy. 2015 Feb;70(2):195-202
pubmed: 25388016
Front Microbiol. 2018 Feb 05;9:84
pubmed: 29467728
Emerg Microbes Infect. 2013 Sep;2(9):e60
pubmed: 26038490
Sci Total Environ. 2020 Apr 15;713:136707
pubmed: 32019041
APMIS. 2013 Jun;121(6):478-93
pubmed: 23127244
Microb Ecol. 2013 Nov;66(4):850-60
pubmed: 23963222
J Immunol. 2010 Aug 1;185(3):1959-67
pubmed: 20592279